The BXH set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in thyroid function (Graves' disease), bone mineral density, atherosclerosis and leukemia. The BXH set is derived from the C57BL/6J (Stock No. 000664) and C3H/HeJ (Stock No. 000659) progenitor strains.
Read More +The BXH set of RI strains is used in the genetic analysis of numerous complex or potentially complex physiologic phenotypes including differences in thyroid function (Graves' disease), bone mineral density, atherosclerosis and leukemia.
A SNP data set is available through the Mouse Phenome Database for the BXH strains.
Another BXH genotype data set consists of 472 MIT CA-repeat dinucleotide microsatellite markers that were typed at UTHSC from 1998 through 2000. The file is taken directly from Williams and colleagues (2001) without any significant modification in genotypes. This order of markers has been updated to conform to the March 2005 assembly of the mouse genome (Build 34 or UCSC mm6). The data set may be downloaded from the University of Tennessee Gene Network site . A data set from Mouse Genome Informatics
Contributed Data Sets is also available.
Tools for using the RI set are presented through the Mouse Phenome Database
Specialized Strain Panel Query Form, and
Gene Network.
This recombinant inbred strain was generated in the laboratory of Dr. Linda Siracusa from an initial cross of a C57BL/6J-Tyrc-2J/Tyrc-2J female by a C3H/HeJ male mouse followed by 16+ generations of brother-sister inbreeding. The mice arrived at The Jackson Laboratory in 2000 at generation F23.
Currently there are no related genes or alleles for this strain.
When using the BXH22/KccJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #003786 in your Materials and Methods section.
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Inbred, 1 pair minimum will be supplied |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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