| Allele Name | transgene insertion 4468, Eric Nestler |
| Allele Type | Transgenic (Inserted expressed sequence) |
| Allele Synonym(s) | TetOp-*FosB line 11; TetOp-deltaFosB line 11 |
| Gene Symbol and Name | Tg(tetFosb)4468Nes, transgene insertion 4468, Eric Nestler |
| Gene Synonym(s) | |
| Promoter | tetO, tet operator, |
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| Expressed Gene | Fosb, FBJ osteosarcoma oncogene B, mouse, laboratory |
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| Site of Expression | When mated to a strain expressing tTA, Fosb expression can be negatively regulated with the tetracycline analog, doxycycline. |
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| Strain of Origin | (SJL x C57BL/6)F1 |
| Chromosome | UN |
| General Note | Homozygous transgenic mice are viable and fertile. These mice express a truncated variant of the Fosb transcription factor. The expressed variant is a highly stable isoform found to be induced in the brain (nucleus accumbens) with repeated exposure to commonly abused drugs, such as amphetamine, morphine, nicotine, and phencyclidine. Transcription is directed by a tetracycline-responsive promoter element (TRE). In bitransgenic mice produced by breeding a mouse carrying this transgene with a transgenic mouse expressing tetracycline-controlled transactivator protein (tTA), Fosb expression can be negatively regulated with the tetracycline analog, doxycycline. |
| Molecular Note | The transgene contains a Fosb cDNA under the control of a tetracycline-regulated promoter, an SV40 intron, and a poly A signal sequence. |
| Mutations Made By | Dr. Eric Nestler, UT Southwestern Medical Center |
