This strain expresses Cdc37 under the direction of a rat probasin promoter resulting in over expression in prostatic epithelia, a tissue where the Cdc37 gene product is absent or present at low levels. While less than ten percent of wildtype littermates develop some degree of hyperplasia by twelve months of age, eighty percent of these transgenic mice exhibit prostatic growth-related disturbances by eight months. Expression is limited to the ventral lobe of the prostate. Correspondingly, hyperplasia is restricted to the ventral prostate. Hyperplasia is frequently accompanied by necrosis. The transgenic insertion site is assumed to be on the Y chromosome as all transgenics are male. In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.

These PB-CDC37 mice express a transgene containing Cdc37 under the direction of a rat probasin promoter, resulting in over expression in prostatic epithelia.

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