PWK was derived from wild mice trapped near Prague, Czech Republic. PWK has a biochemical profile that is similar to the inbred strain PWD (also originating from the Czech Republic - Stock No. <a href="https://www.jax.org/strain/004660">004660</a>) with the exception of the isoenzyme variant esterase 13 (Es13b). Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research. In 2019-2020, researchers at The Jackson Laboratory discovered this inbred strain contains the Trem2S148E allele - a naturally occurring variant at position 48351151-48351152 on Chr 17 (<a href="http://useast.ensembl.org/Mus_musculus/Variation/Sample?db=core;r=17:48351102-48351202;v=rs108080490;vdb=variation;vf=14473644">rs108080490</a> and <a href="http://useast.ensembl.org/Mus_musculus/Variation/Sample?db=core;r=17:48350652-48351652;v=rs107649577;vdb=variation;vf=14110567">rs107649577</a>; Ensembl GRCm38.p6). This TC to GA transition results in a serine to glutamic acid substitution at amino acid 148 (S148E).

This wild-derived inbred strain may be useful for genetic mapping studies.

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