This is one of a series of lines of interval-directed recombinant congenic strains (RCS) with NON/Lt as the background strain. The lines were created by combining variable numbers of known quantitative trait loci (QTL) for obesity and diabetes contributed by New Zealand Obese (NZO/HlLt) and Nonobese Nondiabetic (NON/Lt) strains. Because these lines reflect different collections of obesity and diabetes syndromes QTL, they are extremely relevant as models for the polygenic obesity/ diabesity syndromes in humans.
This is one of a series of lines of interval-directed recombinant congenic strains (RCS) with NON/Lt as the background strain. The lines were created by combining variable numbers of known quantitative trait loci (QTL) for obesity and diabetes contributed by New Zealand Obese (NZO/HlLt) and Nonobese Nondiabetic (NON/Lt) strains. Because these lines reflect different collections of obesity and diabetes syndromes QTL, they are extremely relevant as models for the polygenic obesity/ diabesity syndromes in humans.
This line was created by two backcrosses to NON/Lt of the NON/Lt x NZO/HlLt F1 outcross. At the second backcross (N3), individual mice were identified that were heterozygous for NZO or NON markers previously demonstrated in either F2 or N2 segregation analysis to be associated with the diabetes subphenotypes of elevated plasma glucose (PG), elevated or lowered plasma insulin (PI), and elevated body weight. Such mice were then selectively bred to fix the diabetogenic and nondiabetogenic alleles.
Currently there are no related genes or alleles for this strain.
When using the RCS-3 mouse strain in a publication, please cite the originating article(s) and include JAX stock #003670 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous, 1 pair minimum |
Frozen Mouse Embryo | NONcNZO3/Lt Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | NONcNZO3/Lt Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | NONcNZO3/Lt Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | NONcNZO3/Lt Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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