B6EiC3Sn.BLiAF1/J

Stock number: 003647
Product name: (C57BL/6JEiJ x C3Sn.BLiA-Pde6b⁺/DnJ)F1
Research areas: Mouse/Human Gene Homologs, Sensorineural Research

Description

This F1 hybrid harbors the wild-type allele of Pde6b, and is useful for maintaining fragile mutations on a mixed background without the confounding retinal degeneration.

Detailed description

This F1 hybrid is made using a C3H parent that is congenic for the wild-type allele of Pde6b. Thus, this F1 hybrid is useful for maintaining fragile mutations on a mixed background without the confounding retinal degeneration that is normally found in C3H strains.

Development

This F1 hybrid is made by crossing C57BL/6JEiJ females (Stock No. 000924) with C3Sn.BLiA-Pde6b⁺/Dn (Stock No. 003648). The F1 hybrid offspring are segregating for agouti/nonagouti and are homozygous for the wildtype allele of Pde6b (and thus have normal vision).

Allele

Symbol: Pde6b⁺
Name: wild type
MGI accession ID: MGI:2430003
Generation method: Not Applicable
Marker symbol: Pde6b
Marker name: phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide
Marker synonyms: CSNB3; CSNBAD2; GMP-PDEbeta; nmf137; PDEB; r; rd; rd1; rd10; RP40
Chromosome: 5
Strain of origin: Not Applicable
Expressed genes: Pde6b,phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide,mouse, laboratory
Site of expression: Retina.