These mice carry the frzl spontaneous mutation and are characterized by wavy coat texture and curly whiskers.
Read More +Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Spontaneous | frzl | frizzy-like |
m and Leprdb may still be segregating in this background, but have not been phenotypically detected in at least three cycles of backcross-intercross breeding.
The frizzy like mutation (frzl) phenotypically resembles the frizzy mutation (Prss8fr) and maps to an interval that includes Prss8 but has not been proven to be a mutation in Prss8. Frizzy like homozygotes can be identified by their wavy coat texture and curly whiskers at 7 to 9 days of age, when the first coat comes in. While the curly whiskers persist, the curl of the hair is reduced within a few weeks. At 4 weeks of age a deficiency of zigzag hairs and increased bends in the existing zigzag hairs was found. Because this spontaneous mutation has not been molecularly defined there is currently no genotyping assay for it so the mutation must be identified by phenotype. The frizzy mutation (Prss8fr) is available in stock #000619, FS/EiJ.
The frizzy like mutation arose spontaneously in 1998 in the BKS.Cg-m +/+ Leprdb/J colony at The Jackson Laboratory. This mutant subline was maintained via backcross-intercross and in 2007 sperm was cryopreserved from a homozygous male at generation N3F2.
When using the frizzy-like mouse strain in a publication, please cite the originating article(s) and include JAX stock #003606 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for frzl |
Frozen Mouse Embryo | BKS(Cg)-frzl/GrsrJ | $2595.00 |
Frozen Mouse Embryo | BKS(Cg)-frzl/GrsrJ | $2595.00 |
Frozen Mouse Embryo | BKS(Cg)-frzl/GrsrJ | $3373.50 |
Frozen Mouse Embryo | BKS(Cg)-frzl/GrsrJ | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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