Mice homozygous for the Adra2ctm1Gsb mutation are viable and fertile. They display no gross abnormalities and hemodynamic functions are normal. Homozygotes do show an abnormal response to anesthesia and analgesia. They have also been noted to display an abnormal gait.
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain above. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
|Allele Name||targeted mutation 1, Gregory S Barsh|
|Allele Type||Targeted (Null/Knockout)|
|Allele Synonym(s)||alpha2C-; alpha2C-ARKO; alpha2C-KO|
|Gene Symbol and Name||Adra2c, adrenergic receptor, alpha 2c|
|Strain of Origin||(129X1/SvJ x 129S1/Sv)F1-Kitl+|
|Molecular Note||A neomycin cassette was inserted into the single coding exon. Northern blot analysis and RT-PCR analysis did not detect functional transcript produced from this allele in homozygous mice.|
|Mutations Made By|| |
Dr. Brian Kobilka, Stanford University
Homozygotes are viable and fertile. When maintaining a live colony, homozygous mice may be bred together.
When using the alpha2B- mouse strain in a publication, please cite the originating article(s) and include JAX stock #003557 in your Materials and Methods section.