B6.129S4-Ntf3^tm2Jae/J

Stock number: 003541
Product name: NT-3^2lox
Research areas: Apoptosis Research, Cancer Research, Developmental Biology Research, Immunology, Inflammation and Autoimmunity Research, Neurobiology Research, Research Tools

Description

These floxed mutant mice possess loxP sites flanking the Ntf3 gene. This strain may be useful for generating conditional mutations in applications where Cre recombinase is expressed in cells or tissue of interest.

Detailed description

This strain has loxP sites located on either side of the Ntf3 exon 2. Mice homozygous for this allele are viable, fertile and without behavioral abnormalities. If this strain is crossed with a transgenic strain bearing Cre recombinase, expression of the Ntf3 gene in offspring can be blocked in a tissue-specific manner depending on the promoter controlling the recombinase. Strains under the control of the rat nestin promoter block expression in the central nervous system; see strains 002275 and 002276.

When bred to a strain expressing Cre recombinase in skeletal muscle (see Stock No. 007893 for example), this mutant mouse strain may be useful in studies of muscle spindle development.

When bred to mice carrying Tg(Tagln-cre)1Her (Stock No. 017491)expressing Cre recombinase in smooth muscle, resulting offspring exhbit altered eating behavior.

Development

This strain possesses loxP sites introduced on either side of the Ntf3 exon 2.

Allele

Symbol: Ntf3^tm2Jae
Name: targeted mutation 2, Rudolf Jaenisch
MGI accession ID: MGI:1861706
Generation method: Targeted
Attributes: Conditional ready (e.g. floxed); No functional change
Marker symbol: Ntf3
Marker name: neurotrophin 3
Chromosome: 6
Strain of origin: Not Specified
Molecular note: Introduction of loxP sites flanking exon 2 of the Ntf3 gene.