This strain has loxP sites located on either side of the Ntf3 exon 2. Mice homozygous for this allele are viable, fertile and without behavioral abnormalities. If this strain is crossed with a transgenic strain bearing Cre recombinase, expression of the Ntf3 gene in offspring can be blocked in a tissue-specific manner depending on the promoter controlling the recombinase. Strains under the control of the rat nestin promoter block expression in the central nervous system; see strains <a href="https://www.jax.org/strain/002275">002275</a> and <a href="https://www.jax.org/strain/002276">002276</a>.

 When bred to a strain expressing Cre recombinase in skeletal muscle (see Stock No. <a href="https://www.jax.org/strain/007893">007893</a> for example), this mutant mouse strain may be useful in studies of muscle spindle development.

When bred to mice carrying Tg(Tagln-cre)1Her (Stock No. <a href="https://www.jax.org/strain/017491">017491</a>)expressing Cre recombinase in smooth muscle, resulting offspring exhbit altered eating behavior.

These floxed mutant mice possess loxP sites flanking the Ntf3 gene. This strain may be useful for generating conditional mutations in applications where Cre recombinase is expressed in cells or tissue of interest.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.