Immunologically privileged sites express Fas ligand (FasL), which protects them from attack by activated T cells that express Fas and die upon contact with FasL.  These transgenic mice expresses Fas ligand under the control of a rat insulin promoter, which is active in beta cells of the pancreas. They exhibit heightened sensitivity to diabetogenic T cells, which is due to self-destruction of beta cells upon T cell-mediated induction of Fas.



These RIP-Fasl mice express a transgene containing the Fas ligand under the control of a rat insulin promoter and show heightened sensitivity to diabetogenic T cells.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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