These muCNP-Βgeo transgenic mice express a beta geo fusion protein under the control of murine cyclic nucleotide phosphodiesterase 1 (Cnp1) promoters I and II.
Dr. Lynn D. Hudson, NIH
Genetic Background | Generation |
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Allele Type |
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Transgenic (Reporter) |
This transgenic strain is used to trace glial cell lineage from the early stages throughout their development while simultaneously selecting for oligodendrocytes and Schwann cells. The transgenic mice contain a bacterial b-galactosidase and neomycin phosphotransferase fusion protein (bgeo) under the control of murine 2'3'-cyclic nucleotide 3'-phosphodiesterase (muCNP) promoters I and II. No overt phenotype is observed.
Expressed Gene | Bgeo, fusion of beta-galactosidase and neomycin phosphotransferase genes, E. coli |
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Site of Expression | Glial cell lineage from the early stages throughout their development. |
Allele Name | transgene insertion 1, Lynn D Hudson |
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Allele Type | Transgenic (Reporter) |
Allele Synonym(s) | CNP-GEO |
Gene Symbol and Name | Tg(CNP-GEO)1Ldh, transgene insertion 1, Lynn D Hudson |
Gene Synonym(s) | |
Promoter | CNP, 2',3'-cyclic nucleotide 3' phosphodiesterase, human |
Expressed Gene | Bgeo, fusion of beta-galactosidase and neomycin phosphotransferase genes, E. coli |
Site of Expression | Glial cell lineage from the early stages throughout their development. |
Strain of Origin | (C57BL/6J x C3H)F2 |
Chromosome | UN |
General Note | Transgenic mice exhibit no overt phenotype. |
Molecular Note | The transgene expresses a bacterial beta-galactosidase and neomycin phosphotransferase fusion protein (bgeo) under the control of murine cyclic nucleotide phosphodiesterase 1 (Cnp1) promoters I and II. |
Mutations Made By | Dr. Lynn Hudson, NIH |
When maintaining a live colony, homozygous mice may be bred together.
When using the muCNP-Βgeo mouse strain in a publication, please cite the originating article(s) and include JAX stock #003471 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Hemizygous for Tg(CNP-GEO)1Ldh |
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