Mice with the Htttm2Mem targeted mutation display no overt phenotype. This strain carries 20 CAG repeat units in the first exon of the endogenous Hdh gene. This strain is a control for Stock No's. 003455 and 003456).
Dr. Marcy E MacDonald, Massachusetts General Hospital
This strain carries 20 CAG repeat units in the first exon of the endogenous Htt gene. This strain is on a mixed CD1 x 129 background. The investigator maintains the strain by mating homozygotes.
|Allele Name||targeted mutation 2, Marcy E MacDonald|
|Allele Type||Targeted (Humanized sequence)|
|Gene Symbol and Name||Htt, huntingtin|
|Promoter||Htt, huntingtin, mouse, laboratory|
|Strain of Origin||(129X1/SvJ x 129S1/Sv)F1-Kitl+|
|Molecular Note||This allele carries 18 CAG repeat units, with 20 glutamines, in the first exon of the endogenous gene, modeling the number of CAG repeats found in the human Hdh. It is a derivative of Hdhtm6Mem in which the neo cassette has been removed via cre-mediated recombination.|
|Mutations Made By|| |
Dr. Marcy MacDonald, Massachusetts General Hospital
Homozygotes are viable and fertile. When maintaining a live colony, homozygous mice may be bred together. The coat color expected from breeding is Albino or White Bellied Agouti.
When using the HdhQ20 mouse strain in a publication, please cite the originating article(s) and include JAX stock #003453 in your Materials and Methods section.