Mice with the Htttm2Mem targeted mutation display no overt phenotype. This strain carries 20 CAG repeat units in the first exon of the endogenous Hdh gene. This strain is a control for Stock No's. 003455 and 003456).
Dr. Marcy E MacDonald, Massachusetts General Hospital
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Targeted (Humanized sequence) | Htt | huntingtin |
This strain carries 20 CAG repeat units in the first exon of the endogenous Htt gene. This strain is on a mixed CD1 x 129 background. The investigator maintains the strain by mating homozygotes.
Allele Name | targeted mutation 2, Marcy E MacDonald |
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Allele Type | Targeted (Humanized sequence) |
Allele Synonym(s) | HdhQ20 |
Gene Symbol and Name | Htt, huntingtin |
Gene Synonym(s) | |
Promoter | Htt, huntingtin, mouse, laboratory |
Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl+ |
Chromosome | 5 |
Molecular Note | This allele carries 18 CAG repeat units, with 20 glutamines, in the first exon of the endogenous gene, modeling the number of CAG repeats found in the human Hdh. It is a derivative of Hdhtm6Mem in which the neo cassette has been removed via cre-mediated recombination. |
Mutations Made By | Dr. Marcy MacDonald, Massachusetts General Hospital |
Homozygotes are viable and fertile. When maintaining a live colony, homozygous mice may be bred together. The coat color expected from breeding is Albino or White Bellied Agouti.
When using the HdhQ20 mouse strain in a publication, please cite the originating article(s) and include JAX stock #003453 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous for Htt<tm2Mem>, 1 pair minimum |
Frozen Mouse Embryo | STOCK Htt<tm2Mem>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | STOCK Htt<tm2Mem>/J Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | STOCK Htt<tm2Mem>/J Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | STOCK Htt<tm2Mem>/J Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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