STOCK Htt^tm2Mem/J

Stock number: 003453
Product name: Hdh^Q20
Research areas: Mouse/Human Gene Homologs, Neurobiology Research

Detailed description

Mice with the Htt^tm2Mem targeted mutation display no overt phenotype. This strain carries 20 CAG repeat units in the first exon of the endogenous Hdh gene. This strain is a control for Stock No's. 003455 and 003456).

Development

This strain carries 20 CAG repeat units in the first exon of the endogenous Htt gene. This strain is on a mixed CD1 x 129 background. The investigator maintains the strain by mating homozygotes.

Allele

Symbol: Htt^tm2Mem
Name: targeted mutation 2, Marcy E MacDonald
MGI accession ID: MGI:1861703
Generation method: Targeted
Attributes: Humanized sequence
Synonyms: Hdh^Q20
Marker symbol: Htt
Marker name: huntingtin
Marker synonyms: C430023I11Rik; Hd; Hdh; htt; IT15; LOMARS
Chromosome: 5
Strain of origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺
Molecular note: This allele carries 18 CAG repeat units, with 20 glutamines, in the first exon of the endogenous gene, modeling the number of CAG repeats found in the human Hdh. It is a derivative of Hdh^tm6Mem in which the neo cassette has been removed via cre-mediated recombination.