Females heterozygous for the wavy tiger mutation have curly whiskers and a wavy coat that appears striped. They are small and have smaller litters than normal. Hemizygous males on this background rarely survive to adulthood and those that do will fail to breed. The sperm has diminished motility.Read More +
Females heterozygous for the wavy tiger mutation have curly whiskers and a wavy coat that appears striped. They are small and have smaller litters than normal. Hemizygous males on this background rarely survive to adulthood and those that do will fail to breed. The sperm has diminished motility.
The X-linked wavy tiger mutation occurred on a DBA/2J-derived X Chromosome in a fully DBA/2J congenic strain carrying C57BL/6J-derived loci from Chromosomes 2 and 4: intervals D2Mit6, D2Mit61, D2Mit66 and D4Mit42, D4Smh6b, Dvl1 respectively. The strain of origin for wavy tiger also contained the Mus poschiavinus Y Chromosome, which was subsequently removed and replaced with a DBA/2J Y Chromosome by an outcross of a heterozygous wavy tiger female to a DBA/2J male. The genetic background of this strain may still harbor any of the C57BL/6J-derived loci given above.
|Allele Name||wavy tiger|
|Allele Synonym(s)||wavy tiger; Ophn1Wtgr|
|Gene Symbol and Name||Ophn1, oligophrenin 1|
|Gene Synonym(s)||ARHGAP41; C130037N19Rik; C130037N19Rik; OPN1; MRX60; RIKEN cDNA C130037N19 gene; Wtgr; wavy tiger; Wtgr; Opn1|
|Strain of Origin||DBA/2J|
|Molecular Note||An A-to-C point mutation at postition 1639 of the cDNA (NM_052976) is predicted to result in a lysine to glutamine substitution at position 547 of the encoded protein (p.K547Q).|
|Heterozygous for Wtgr females, Wild-type for Wtgr males|
We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
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