Females heterozygous for the wavy tiger mutation have curly whiskers and a wavy coat that appears striped. They are small and have smaller litters than normal. Hemizygous males on this background rarely survive to adulthood and those that do will fail to breed. The sperm has diminished motility.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Ophn1 | oligophrenin 1 |
Females heterozygous for the wavy tiger mutation have curly whiskers and a wavy coat that appears striped. They are small and have smaller litters than normal. Hemizygous males on this background rarely survive to adulthood and those that do will fail to breed. The sperm has diminished motility.
The X-linked wavy tiger mutation occurred on a DBA/2J-derived X Chromosome in a fully DBA/2J congenic strain carrying C57BL/6J-derived loci from Chromosomes 2 and 4: intervals D2Mit6, D2Mit61, D2Mit66 and D4Mit42, D4Smh6b, Dvl1 respectively. The strain of origin for wavy tiger also contained the Mus poschiavinus Y Chromosome, which was subsequently removed and replaced with a DBA/2J Y Chromosome by an outcross of a heterozygous wavy tiger female to a DBA/2J male. The genetic background of this strain may still harbor any of the C57BL/6J-derived loci given above.
Allele Name | wavy tiger |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Ophn1, oligophrenin 1 |
Gene Synonym(s) | |
Strain of Origin | DBA/2J |
Chromosome | X |
Molecular Note | An A-to-C point mutation at coding nucleotide 1639 of the cDNA (NM_052976) results in a lysine to glutamine substitution at position 547 of the encoded protein (p.K547Q). |
When using the D2(B6)-Ophn1Wtgr/EiGrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #003397 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for Wtgr females, Wild-type for Wtgr males |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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