Females heterozygous for the wavy tiger mutation have curly whiskers and a wavy coat that appears striped. They are small and have smaller litters than normal. Hemizygous males on this background rarely survive to adulthood and those that do will fail to breed. The sperm has diminished motility.Read More +
Females heterozygous for the wavy tiger mutation have curly whiskers and a wavy coat that appears striped. They are small and have smaller litters than normal. Hemizygous males on this background rarely survive to adulthood and those that do will fail to breed. The sperm has diminished motility.
The X-linked wavy tiger mutation occurred on a DBA/2J-derived X Chromosome in a fully DBA/2J congenic strain carrying C57BL/6J-derived loci from Chromosomes 2 and 4: intervals D2Mit6, D2Mit61, D2Mit66 and D4Mit42, D4Smh6b, Dvl1 respectively. The strain of origin for wavy tiger also contained the Mus poschiavinus Y Chromosome, which was subsequently removed and replaced with a DBA/2J Y Chromosome by an outcross of a heterozygous wavy tiger female to a DBA/2J male. The genetic background of this strain may still harbor any of the C57BL/6J-derived loci given above.
|Allele Name||wavy tiger|
|Gene Symbol and Name||Ophn1, oligophrenin 1|
|Strain of Origin||DBA/2J|
|Molecular Note||An A-to-C point mutation at coding nucleotide 1639 of the cDNA (NM_052976) results in a lysine to glutamine substitution at position 547 of the encoded protein (p.K547Q).|
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