CD1-Tg(Igh-HOX11)11Idd/J

Stock number: 003395
Product name: HOX11
Research areas: Cancer Research, Cell Biology Research, Developmental Biology Research, Hematological Research, Research Tools

Description

These HOX11 mice express a transgene containing the human HOX11 (TLX1/HOX11) cDNA under the control of the murine Igh-V region promoter fused to the IgH enhancer with expression detected in the kidney, bone marrow, and spleen tissue.

Detailed description

This transgenic strain is a good tool for developing therapies for non-Hodgkins lymphoma. Heterozygous mice appear normal and healthy at birth but die in their second year of life. More than 85% of of these mice die from mature B cell lymphoma. No homozygous TLX1 mice were identified in offspring of heterozygous matings, suggesting that homozygotes are not viable.

Allele

Symbol: Tg(Igh-HOX11)11Idd
Name: transgene insertion 11, Ian Dube
MGI accession ID: MGI:2429404
Generation method: Transgenic
Attributes: Inserted expressed sequence
Marker symbol: Tg(Igh-HOX11)11Idd
Marker name: transgene insertion 11, Ian Dube
Chromosome: UN
Strain of origin: CD-1
Expressed genes: TLX1,T cell leukemia homeobox 1,human
Molecular note: Human HOX11 cDNA was placed under the control of the murine Igh-V region promoter fused to the IgH enhancer. Expression of HOX11 was detected in the kidney via Northern blot analysis and in bone marrow and speen tissue via RNAse protection. Founder mice carried between 2 and 4 copies of the transgenic construct.