JAX
Mouse Strain Datasheet - 003377
FVB/N-Tg(Zp3-cre)3Mrt/J
Also Known As: Zp3-cre
These Zp3-cre mice express a transgene containing cre with the mouse zona pellucida 3 (Zp3) promoter.
Donating Investigator
Dr. Gail Martin, University of California San Francisco
Genetic overview
| Genetic Background | Generation |
|---|---|
|
|
Tg(Zp3-cre)3Mrt
| Allele Type |
|---|
| Transgenic (Recombinase-expressing) |
Detailed Description
The strain originated on an FVB/N background and is currently on the same background. The investigator maintains the strain by breeding hemizygotes. Homozygotes are subfertile. This is a transgenic line in which cre expression is controlled by the regulatory sequences from the mouse zona pellucida 3 (Zp3) gene, which is normally expressed exclusively in the growing oocyte prior to the completion of the first meiotic division. This strain would be useful for deleting a floxed sequence specifically in the female germ line.
Development
A CreZp3 construct was injected into FVB/N zygotes to produce the founder line. The strain originated on an FVB/N background and is currently on the same background. Female homozygotes are subfertile.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | prior to first meiotic division |
Control Suggestions
Selected References
- Lewandoski M; Wassarman KM; Martin GR. 1997. Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line.. In: . . MGI: J:50993
Tg(Zp3-cre)3Mrt
Allele Symbol: Tg(Zp3-cre)3Mrt
| Allele Name | transgene insertion 3, Gail R Martin |
|---|---|
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | Zp3-cre; Zp3::Cre; delta-R |
| Gene Symbol and Name | Tg(Zp3-cre)3Mrt, transgene insertion 3, Gail R Martin |
| Gene Synonym(s) | Zp3-cre; delta-R |
| Promoter | Zp3, zona pellucida glycoprotein 3, mouse, laboratory |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | prior to first meiotic division |
| Strain of Origin | FVB/N |
| Chromosome | UN |
| General Note | Homozygous transgenic mice are viable and fertile. |
| Molecular Note | This transgene expresses NLS-Cre recombinase under the control of a mouse zona pellucida 3 promoter. This promoter is active in oocytes. No expression was detected in somatic tissues. |
| Mutations Made By | Dr. Gail Martin, University of California San Francisco |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Cre Recombinase Expression: Germline/Embryonic Expression
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Reproductive Biology Research
- Cre-lox System
- oocyte
- Cre-lox System
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
Mammalian Phenotype Terms by Genotype
Genotype: Tg(Zp3-cre)3Mrt/Tg(Zp3-cre)3Mrt
FVB/N-Tg(Zp3-cre)3Mrt/J
reproductive system phenotype
- reduced female fertility
- females are subfertile, producing an average of 3.7 pups per litter (MGI Ref ID J:67903)
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Tg(Zp3-cre)3Mrt/0
B6.FVB-Tg(Zp3-cre)3Mrt
reproductive system phenotype
- reduced female fertility
- females are subfertile, producing an average of 2.5 pups per litter (MGI Ref ID J:67903)
References
- Lewandoski M; Wassarman KM; Martin GR. 1997. Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line.. In: . . MGI: J:50993
Additional References
- de Vries WN; Binns LT; Fancher KS; Dean J; Moore R; Kemler R; Knowles BB. 2000. Expression of Cre recombinase in mouse oocytes: a means to study maternal effect genes.. In: . . MGI: J:67903
Additional - Tg(Zp3-cre)3Mrt related
- Alvarez-Saavedra M; De Repentigny Y; Lagali PS; Raghu Ram EV; Yan K; Hashem E; Ivanochko D; Huh MS; Yang D; Mears AJ; Todd MA; Corcoran CP; Bassett EA; Tokarew NJ; Kokavec J; Majumder R; Ioshikhes I; Wallace VA; Kothary R; Meshorer E; Stopka T; Skoultchi AI; Picketts DJ. 2014. Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation.. In: . . MGI: J:225216
- Andreu-Vieyra CV; Chen R; Agno JE; Glaser S; Anastassiadis K; Stewart AF; Matzuk MM. 2010. MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing.. In: . . MGI: J:166778
- Artus J; Piliszek A; Hadjantonakis AK. 2011. The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17.. In: . . MGI: J:170416
- Astrakhan A; Sather BD; Ryu BY; Khim S; Singh S; Humblet-Baron S; Ochs HD; Miao CH; Rawlings DJ. 2012. Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome.. In: . . MGI: J:185176
- Audouard C; Le Masson F; Charry C; Li Z; Christians ES. 2011. Oocyte-targeted deletion reveals that hsp90b1 is needed for the completion of first mitosis in mouse zygotes.. In: . . MGI: J:171086
- Balboula AZ; Schindler K. 2014. Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes.. In: . . MGI: J:211004
- Balthasar N; Dalgaard LT; Lee CE; Yu J; Funahashi H; Williams T; Ferreira M; Tang V; McGovern RA; Kenny CD; Christiansen LM; Edelstein E; Choi B; Boss O; Aschkenasi C; Zhang CY; Mountjoy K; Kishi T; Elmquist JK; Lowell BB. 2005. Divergence of melanocortin pathways in the control of food intake and energy expenditure.. In: . . MGI: J:115192
- Bedzhov I; Liszewska E; Kanzler B; Stemmler MP. 2012. Igf1r signaling is indispensable for preimplantation development and is activated via a novel function of E-cadherin.. In: . . MGI: J:183847
- Ben-Meir A; Burstein E; Borrego-Alvarez A; Chong J; Wong E; Yavorska T; Naranian T; Chi M; Wang Y; Bentov Y; Alexis J; Meriano J; Sung HK; Gasser DL; Moley KH; Hekimi S; Casper RF; Jurisicova A. 2015. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging.. In: . . MGI: J:227578
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- Biechele S; Cockburn K; Lanner F; Cox BJ; Rossant J. 2013. Porcn-dependent Wnt signaling is not required prior to mouse gastrulation.. In: . . MGI: J:198636
- Boillee S; Yamanaka K; Lobsiger CS; Copeland NG; Jenkins NA; Kassiotis G; Kollias G; Cleveland DW. 2006. Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia.. In: . . MGI: J:109131
- Brydges SD; Mueller JL; McGeough MD; Pena CA; Misaghi A; Gandhi C; Putnam CD; Boyle DL; Firestein GS; Horner AA; Soroosh P; Watford WT; O'Shea JJ; Kastner DL; Hoffman HM. 2009. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.. In: . . MGI: J:150054
- Bultman SJ; Gebuhr TC; Pan H; Svoboda P; Schultz RM; Magnuson T. 2006. Maternal BRG1 regulates zygotic genome activation in the mouse.. In: . . MGI: J:110234
- Chen YT; Tsai MS; Yang TL; Ku AT; Huang KH; Huang CY; Chou FJ; Fan HH; Hong JB; Yen ST; Wang WL; Lin CC; Hsu YC; Su KY; Su IC; Jang CW; Behringer RR; Favaro R; Nicolis SK; Chien CL; Lin SW; Yu IS. 2012. R26R-GR: a Cre-activable dual fluorescent protein reporter mouse.. In: . . MGI: J:191943
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- Duan X; Krishnaswamy A; De la Huerta I; Sanes JR. 2014. Type II cadherins guide assembly of a direction-selective retinal circuit.. In: . . MGI: J:214586
- Dy P; Smits P; Silvester A; Penzo-Mendez A; Dumitriu B; Han Y; de la Motte CA; Kingsley DM; Lefebvre V. 2010. Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage.. In: . . MGI: J:160493
- Fernandez-Valdivia R; Jeong J; Mukherjee A; Soyal SM; Li J; Ying Y; Demayo FJ; Lydon JP. 2010. A mouse model to dissect progesterone signaling in the female reproductive tract and mammary gland.. In: . . MGI: J:158406
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- Fitzpatrick GV; Soloway PD; Higgins MJ. 2002. Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1. In: . . MGI: J:79882
- Froese A; Breher SS; Waldeyer C; Schindler RF; Nikolaev VO; Rinne S; Wischmeyer E; Schlueter J; Becher J; Simrick S; Vauti F; Kuhtz J; Meister P; Kreissl S; Torlopp A; Liebig SK; Laakmann S; Muller TD; Neumann J; Stieber J; Ludwig A; Maier SK; Decher N; Arnold HH; Kirchhof P; Fabritz L; Brand T. 2012. Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice.. In: . . MGI: J:184566
- Gardam S; Sierro F; Basten A; Mackay F; Brink R. 2008. TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.. In: . . MGI: J:132877
- Gatto D; Paus D; Basten A; Mackay CR; Brink R. 2009. Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses.. In: . . MGI: J:151883
- Gazdag E; Santenard A; Ziegler-Birling C; Altobelli G; Poch O; Tora L; Torres-Padilla ME. 2009. TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte.. In: . . MGI: J:152449
- Gebuhr TC; Kovalev GI; Bultman S; Godfrey V; Su L; Magnuson T. 2003. The role of Brg1, a catalytic subunit of mammalian chromatin-remodeling complexes, in T cell development.. In: . . MGI: J:87219
- Gershon E; Plaks V; Aharon I; Galiani D; Reizel Y; Sela-Abramovich S; Granot I; Winterhager E; Dekel N. 2008. Oocyte-directed depletion of connexin43 using the Cre-LoxP system leads to subfertility in female mice.. In: . . MGI: J:130120
- Gilchrist DS; Ure J; Hook L; Medvinsky A. 2003. Labeling of hematopoietic stem and progenitor cells in novel activatable EGFP reporter mice.. In: . . MGI: J:135901
- Grasa P; Kaune H; Williams SA. 2012. Embryos generated from oocytes lacking complex N- and O-glycans have compromised development and implantation.. In: . . MGI: J:191575
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- Hagglund AC; Berghard A; Carlsson L. 2013. Canonical Wnt/beta-catenin signalling is essential for optic cup formation.. In: . . MGI: J:210692
- He B; Kim TH; Kommagani R; Feng Q; Lanz RB; Jeong JW; DeMayo FJ; Katzenellenbogen BS; Lydon JP; O'Malley BW. 2011. Estrogen-regulated prohibitin is required for mouse uterine development and adult function.. In: . . MGI: J:173884
- He H; Wang Y; Guo X; Ramchandani S; Ma J; Shen MF; Garcia DA; Deng Y; Multani AS; You MJ; Chang S. 2009. Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita.. In: . . MGI: J:144553
- Herman H; Lu M; Anggraini M; Sikora A; Chang Y; Yoon BJ; Soloway PD. 2003. Trans allele methylation and paramutation-like effects in mice.. In: . . MGI: J:85825
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- Holmes R; Chang Y; Soloway PD. 2006. Timing and sequence requirements defined for embryonic maintenance of imprinted DNA methylation at Rasgrf1.. In: . . MGI: J:117666
- Huang QQ; Perlman H; Huang Z; Birkett R; Kan L; Agrawal H; Misharin A; Gurbuxani S; Crispino JD; Pope RM. 2010. FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis.. In: . . MGI: J:167430
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- Jin N; Gilbert JL; Broaddus RR; Demayo FJ; Jeong JW. 2007. Generation of a Mig-6 conditional null allele.. In: . . MGI: J:129106
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- Kim J; Singh AK; Takata Y; Lin K; Shen J; Lu Y; Kerenyi MA; Orkin SH; Chen T. 2015. LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice.. In: . . MGI: J:227995
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- Levin SI; Meisler MH. 2004. Floxed allele for conditional inactivation of the voltage-gated sodium channel Scn8a (Na(v)1.6).. In: . . MGI: J:91696
- Li G; Zhou L; Zhu Y; Wang C; Sha S; Xian X; Ji Y; Liu G; Chen L. 2015. Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARgamma.. In: . . MGI: J:226846
- Li H; Wang D; Singh LS; Berk M; Tan H; Zhao Z; Steinmetz R; Kirmani K; Wei G; Xu Y. 2009. Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1.. In: . . MGI: J:149315
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- Li Y; Yu S; Duncan T; Li Y; Liu P; Gene E; Cortes-Pena Y; Qian H; Dong L; Redmond TM. 2015. Mouse model of human RPE65 P25L hypomorph resembles wild type under normal light rearing but is fully resistant to acute light damage.. In: . . MGI: J:223999
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- Neves P; Lampropoulou V; Calderon-Gomez E; Roch T; Stervbo U; Shen P; Kuhl AA; Loddenkemper C; Haury M; Nedospasov SA; Kaufmann SH; Steinhoff U; Calado DP; Fillatreau S. 2010. Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection.. In: . . MGI: J:167006
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