These Zp3-cre mice express a transgene containing cre with the mouse zona pellucida 3 (Zp3) promoter.
Dr. Gail Martin, University of California San Francisco
Genetic Background | Generation |
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Allele Type |
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Transgenic (Recombinase-expressing) |
The strain originated on an FVB/N background and is currently on the same background. The investigator maintains the strain by breeding hemizygotes. Homozygotes are subfertile. This is a transgenic line in which cre expression is controlled by the regulatory sequences from the mouse zona pellucida 3 (Zp3) gene, which is normally expressed exclusively in the growing oocyte prior to the completion of the first meiotic division. This strain would be useful for deleting a floxed sequence specifically in the female germ line.
A CreZp3 construct was injected into FVB/N zygotes to produce the founder line. The strain originated on an FVB/N background and is currently on the same background. Female homozygotes are subfertile.
Expressed Gene | cre, cre recombinase, bacteriophage P1 |
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Site of Expression | prior to first meiotic division |
Allele Name | transgene insertion 3, Gail R Martin |
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Allele Type | Transgenic (Recombinase-expressing) |
Allele Synonym(s) | delta-R; Zp3::Cre; Zp3-cre |
Gene Symbol and Name | Tg(Zp3-cre)3Mrt, transgene insertion 3, Gail R Martin |
Gene Synonym(s) | |
Promoter | Zp3, zona pellucida glycoprotein 3, mouse, laboratory |
Expressed Gene | cre, cre recombinase, bacteriophage P1 |
Site of Expression | prior to first meiotic division |
Strain of Origin | FVB/N |
Chromosome | UN |
General Note | Homozygous transgenic mice are viable and fertile. |
Molecular Note | This transgene expresses NLS-Cre recombinase under the control of a mouse zona pellucida 3 promoter. This promoter is active in oocytes. No expression was detected in somatic tissues. |
Mutations Made By | Dr. Gail Martin, University of California San Francisco |
Homozygotes are viable, but homozygous females may be subfertile. When maintaining a live colony, transgene carrier mice may be bred together, to wildtype (non-carrier) mice from the colony or to FVB/NJ inbred mice (Stock No. 001800). The expected coat color from breeding is albino.
When using the Zp3-cre mouse strain in a publication, please cite the originating article(s) and include JAX stock #003377 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Hemizygous for Tg(Zp3-cre)3Mrt |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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