JAX
Mouse Strain Datasheet - 003377
FVB/N-Tg(Zp3-cre)3Mrt/J
Also Known As: Zp3-cre
These Zp3-cre mice express a transgene containing cre with the mouse zona pellucida 3 (Zp3) promoter.
Donating Investigator
Dr. Gail Martin, University of California San Francisco
Genetic overview
| Genetic Background | Generation |
|---|---|
|
|
Tg(Zp3-cre)3Mrt
| Allele Type |
|---|
| Transgenic (Recombinase-expressing) |
Detailed Description
The strain originated on an FVB/N background and is currently on the same background. The investigator maintains the strain by breeding hemizygotes. Homozygotes are subfertile. This is a transgenic line in which cre expression is controlled by the regulatory sequences from the mouse zona pellucida 3 (Zp3) gene, which is normally expressed exclusively in the growing oocyte prior to the completion of the first meiotic division. This strain would be useful for deleting a floxed sequence specifically in the female germ line.
Development
A CreZp3 construct was injected into FVB/N zygotes to produce the founder line. The strain originated on an FVB/N background and is currently on the same background. Female homozygotes are subfertile.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | prior to first meiotic division |
Control Suggestions
Selected References
- Lewandoski M; Wassarman KM; Martin GR. 1997. Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line. Curr Biol 7(2):148-51. PubMed: 9016703MGI: J:50993
Tg(Zp3-cre)3Mrt
Allele Symbol: Tg(Zp3-cre)3Mrt
| Allele Name | transgene insertion 3, Gail R Martin |
|---|---|
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | Zp3-cre; Zp3::Cre; delta-R |
| Gene Symbol and Name | Tg(Zp3-cre)3Mrt, transgene insertion 3, Gail R Martin |
| Gene Synonym(s) | Zp3-cre; delta-R |
| Promoter | Zp3, zona pellucida glycoprotein 3, mouse, laboratory |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | prior to first meiotic division |
| Strain of Origin | FVB/N |
| Chromosome | UN |
| General Note | Homozygous transgenic mice are viable and fertile. |
| Molecular Note | This transgene expresses NLS-Cre recombinase under the control of a mouse zona pellucida 3 promoter. This promoter is active in oocytes. No expression was detected in somatic tissues. |
| Mutations Made By | Dr. Gail Martin, University of California San Francisco |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Cre Recombinase Expression: Germline/Embryonic Expression
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Reproductive Biology Research
- Cre-lox System
- oocyte
- Cre-lox System
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
Mammalian Phenotype Terms by Genotype
Genotype: Tg(Zp3-cre)3Mrt/Tg(Zp3-cre)3Mrt
FVB/N-Tg(Zp3-cre)3Mrt/J
reproductive system phenotype
- reduced female fertility
- females are subfertile, producing an average of 3.7 pups per litter (MGI Ref ID J:67903)
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Tg(Zp3-cre)3Mrt/0
B6.FVB-Tg(Zp3-cre)3Mrt
reproductive system phenotype
- reduced female fertility
- females are subfertile, producing an average of 2.5 pups per litter (MGI Ref ID J:67903)
References
- Lewandoski M; Wassarman KM; Martin GR. 1997. Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line. Curr Biol 7(2):148-51. PubMed: 9016703MGI: J:50993
Additional References
- de Vries WN; Binns LT; Fancher KS; Dean J; Moore R; Kemler R; Knowles BB. 2000. Expression of Cre recombinase in mouse oocytes: a means to study maternal effect genes. Genesis 26(2):110-2. PubMed: 10686600MGI: J:67903
Additional - Tg(Zp3-cre)3Mrt related
- Alvarez-Saavedra M; De Repentigny Y; Lagali PS; Raghu Ram EV; Yan K; Hashem E; Ivanochko D; Huh MS; Yang D; Mears AJ; Todd MA; Corcoran CP; Bassett EA; Tokarew NJ; Kokavec J; Majumder R; Ioshikhes I; Wallace VA; Kothary R; Meshorer E; Stopka T; Skoultchi AI; Picketts DJ. 2014. Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation. Nat Commun 5:4181. PubMed: 24946904MGI: J:225216
- Andreu-Vieyra CV; Chen R; Agno JE; Glaser S; Anastassiadis K; Stewart AF; Matzuk MM. 2010. MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing. PLoS Biol 8(8):. PubMed: 20808952MGI: J:166778
- Artus J; Piliszek A; Hadjantonakis AK. 2011. The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17. Dev Biol 350(2):393-404. PubMed: 21146513MGI: J:170416
- Astrakhan A; Sather BD; Ryu BY; Khim S; Singh S; Humblet-Baron S; Ochs HD; Miao CH; Rawlings DJ. 2012. Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome. Blood 119(19):4395-407. PubMed: 22431569MGI: J:185176
- Audouard C; Le Masson F; Charry C; Li Z; Christians ES. 2011. Oocyte-targeted deletion reveals that hsp90b1 is needed for the completion of first mitosis in mouse zygotes. PLoS One 6(2):e17109. PubMed: 21358806MGI: J:171086
- Balboula AZ; Schindler K. 2014. Selective disruption of aurora C kinase reveals distinct functions from aurora B kinase during meiosis in mouse oocytes. PLoS Genet 10(2):e1004194. PubMed: 24586209MGI: J:211004
- Balthasar N; Dalgaard LT; Lee CE; Yu J; Funahashi H; Williams T; Ferreira M; Tang V; McGovern RA; Kenny CD; Christiansen LM; Edelstein E; Choi B; Boss O; Aschkenasi C; Zhang CY; Mountjoy K; Kishi T; Elmquist JK; Lowell BB. 2005. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123(3):493-505. PubMed: 16269339MGI: J:115192
- Bedzhov I; Liszewska E; Kanzler B; Stemmler MP. 2012. Igf1r signaling is indispensable for preimplantation development and is activated via a novel function of E-cadherin. PLoS Genet 8(3):e1002609. PubMed: 22479204MGI: J:183847
- Ben-Meir A; Burstein E; Borrego-Alvarez A; Chong J; Wong E; Yavorska T; Naranian T; Chi M; Wang Y; Bentov Y; Alexis J; Meriano J; Sung HK; Gasser DL; Moley KH; Hekimi S; Casper RF; Jurisicova A. 2015. Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging. Aging Cell 14(5):887-95. PubMed: 26111777MGI: J:227578
- Bhattaram P; Penzo-Mendez A; Sock E; Colmenares C; Kaneko KJ; Vassilev A; Depamphilis ML; Wegner M; Lefebvre V. 2010. Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors. Nat Commun 1:9. PubMed: 20596238MGI: J:175338
- Biechele S; Cockburn K; Lanner F; Cox BJ; Rossant J. 2013. Porcn-dependent Wnt signaling is not required prior to mouse gastrulation. Development 140(14):2961-71. PubMed: 23760955MGI: J:198636
- Boillee S; Yamanaka K; Lobsiger CS; Copeland NG; Jenkins NA; Kassiotis G; Kollias G; Cleveland DW. 2006. Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia. Science 312(5778):1389-92. PubMed: 16741123MGI: J:109131
- Brydges SD; Mueller JL; McGeough MD; Pena CA; Misaghi A; Gandhi C; Putnam CD; Boyle DL; Firestein GS; Horner AA; Soroosh P; Watford WT; O'Shea JJ; Kastner DL; Hoffman HM. 2009. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 30(6):875-87. PubMed: 19501000MGI: J:150054
- Bultman SJ; Gebuhr TC; Pan H; Svoboda P; Schultz RM; Magnuson T. 2006. Maternal BRG1 regulates zygotic genome activation in the mouse. Genes Dev 20(13):1744-54. PubMed: 16818606MGI: J:110234
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- Clarke M; Dumon S; Ward C; Jager R; Freeman S; Dawood B; Sheriff L; Lorvellec M; Kralovics R; Frampton J; Garcia P. 2013. MYBL2 haploinsufficiency increases susceptibility to age-related haematopoietic neoplasia. Leukemia 27(3):661-70. PubMed: 22910183MGI: J:196804
- Cui X; Wang Y; Tang Y; Liu Y; Zhao L; Deng J; Xu G; Peng X; Ju S; Liu G; Yang H. 2011. Seipin ablation in mice results in severe generalized lipodystrophy. Hum Mol Genet 20(15):3022-30. PubMed: 21551454MGI: J:173404
- Ding JH; Xu X; Yang D; Chu PH; Dalton ND; Ye Z; Yeakley JM; Cheng H; Xiao RP; Ross J; Chen J; Fu XD. 2004. Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J 23(4):885-96. PubMed: 14963485MGI: J:88432
- Duan X; Krishnaswamy A; De la Huerta I; Sanes JR. 2014. Type II cadherins guide assembly of a direction-selective retinal circuit. Cell 158(4):793-807. PubMed: 25126785MGI: J:214586
- Dy P; Smits P; Silvester A; Penzo-Mendez A; Dumitriu B; Han Y; de la Motte CA; Kingsley DM; Lefebvre V. 2010. Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage. Dev Biol 341(2):346-59. PubMed: 20206616MGI: J:160493
- Fernandez-Valdivia R; Jeong J; Mukherjee A; Soyal SM; Li J; Ying Y; Demayo FJ; Lydon JP. 2010. A mouse model to dissect progesterone signaling in the female reproductive tract and mammary gland. Genesis 48(2):106-13. PubMed: 20029965MGI: J:158406
- Ferreira R; Wai A; Shimizu R; Gillemans N; Rottier R; von Lindern M; Ohneda K; Grosveld F; Yamamoto M; Philipsen S. 2007. Dynamic regulation of Gata factor levels is more important than their identity. Blood 109(12):5481-90. PubMed: 17327407MGI: J:145425
- Fitzpatrick GV; Soloway PD; Higgins MJ. 2002. Regional loss of imprinting and growth deficiency in mice with a targeted deletion of KvDMR1 Nat Genet 32(3):426-31. PubMed: 12410230MGI: J:79882
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- Gardam S; Sierro F; Basten A; Mackay F; Brink R. 2008. TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity 28(3):391-401. PubMed: 18313334MGI: J:132877
- Gatto D; Paus D; Basten A; Mackay CR; Brink R. 2009. Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity 31(2):259-69. PubMed: 19615922MGI: J:151883
- Gazdag E; Santenard A; Ziegler-Birling C; Altobelli G; Poch O; Tora L; Torres-Padilla ME. 2009. TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte. Genes Dev 23(18):2210-23. PubMed: 19759265MGI: J:152449
- Gebuhr TC; Kovalev GI; Bultman S; Godfrey V; Su L; Magnuson T. 2003. The role of Brg1, a catalytic subunit of mammalian chromatin-remodeling complexes, in T cell development. J Exp Med 198(12):1937-49. PubMed: 14676303MGI: J:87219
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- Grasa P; Kaune H; Williams SA. 2012. Embryos generated from oocytes lacking complex N- and O-glycans have compromised development and implantation. Reproduction 144(4):455-65. PubMed: 22919046MGI: J:191575
- Grasa P; Sheikh S; Krzys N; Millar K; Janjua S; Nawaggi P; Williams SA. 2016. Dysregulation of follicle development in a mouse model of premature ovarian insufficiency. Reproduction 152(5):591-601. PubMed: 27581083MGI: J:237228
- Gu TP; Guo F; Yang H; Wu HP; Xu GF; Liu W; Xie ZG; Shi L; He X; Jin SG; Iqbal K; Shi YG; Deng Z; Szabo PE; Pfeifer GP; Li J; Xu GL. 2011. The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature 477(7366):606-10. PubMed: 21892189MGI: J:176196
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- He H; Wang Y; Guo X; Ramchandani S; Ma J; Shen MF; Garcia DA; Deng Y; Multani AS; You MJ; Chang S. 2009. Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita. Mol Cell Biol 29(1):229-40. PubMed: 18936156MGI: J:144553
- Herman H; Lu M; Anggraini M; Sikora A; Chang Y; Yoon BJ; Soloway PD. 2003. Trans allele methylation and paramutation-like effects in mice. Nat Genet 34(2):199-202. PubMed: 12740578MGI: J:85825
- Hoch RV; Clarke JA; Rubenstein JL. 2015. Fgf signaling controls the telencephalic distribution of Fgf-expressing progenitors generated in the rostral patterning center. Neural Dev 10:8. PubMed: 25889070MGI: J:222259
- Holmes R; Chang Y; Soloway PD. 2006. Timing and sequence requirements defined for embryonic maintenance of imprinted DNA methylation at Rasgrf1. Mol Cell Biol 26(24):9564-70. PubMed: 17030618MGI: J:117666
- Huang QQ; Perlman H; Huang Z; Birkett R; Kan L; Agrawal H; Misharin A; Gurbuxani S; Crispino JD; Pope RM. 2010. FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis. Blood 116(23):4968-77. PubMed: 20724542MGI: J:167430
- Hui ST; Andres AM; Miller AK; Spann NJ; Potter DW; Post NM; Chen AZ; Sachithanantham S; Jung DY; Kim JK; Davis RA. 2008. Txnip balances metabolic and growth signaling via PTEN disulfide reduction. Proc Natl Acad Sci U S A 105(10):3921-6. PubMed: 18322014MGI: J:132756
- Jin N; Gilbert JL; Broaddus RR; Demayo FJ; Jeong JW. 2007. Generation of a Mig-6 conditional null allele. Genesis 45(11):716-21. PubMed: 17987665MGI: J:129106
- Juan HC; Lin Y; Chen HR; Fann MJ. 2016. Cdk12 is essential for embryonic development and the maintenance of genomic stability. Cell Death Differ 23(6):1038-48. PubMed: 26658019MGI: J:242195
- Kang J; Lienhard M; Pastor WA; Chawla A; Novotny M; Tsagaratou A; Lasken RS; Thompson EC; Surani MA; Koralov SB; Kalantry S; Chavez L; Rao A. 2015. Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis. Proc Natl Acad Sci U S A 112(31):E4236-45. PubMed: 26199412MGI: J:226048
- Kang M; Piliszek A; Artus J; Hadjantonakis AK. 2013. FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse. Development 140(2):267-79. PubMed: 23193166MGI: J:191065
- Kim J; Singh AK; Takata Y; Lin K; Shen J; Lu Y; Kerenyi MA; Orkin SH; Chen T. 2015. LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice. Nat Commun 6:10116. PubMed: 26626423MGI: J:227995
- Ko G; Paradise S; Chen H; Graham M; Vecchi M; Bianchi F; Cremona O; Di Fiore PP; De Camilli P. 2010. Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculi. Proc Natl Acad Sci U S A :. PubMed: 21115825MGI: J:167134
- Komatsu M; Waguri S; Ueno T; Iwata J; Murata S; Tanida I; Ezaki J; Mizushima N; Ohsumi Y; Uchiyama Y; Kominami E; Tanaka K; Chiba T. 2005. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 169(3):425-34. PubMed: 15866887MGI: J:100199
- Korotkevich E; Niwayama R; Courtois A; Friese S; Berger N; Buchholz F; Hiiragi T. 2017. The Apical Domain Is Required and Sufficient for the First Lineage Segregation in the Mouse Embryo. Dev Cell 40(3):235-247.e7. PubMed: 28171747MGI: J:239148
- Kraus P; V S; Yu HB; Xing X; Lim SL; Adler T; Pimentel JA; Becker L; Bohla A; Garrett L; Hans W; Holter SM; Janas E; Moreth K; Prehn C; Puk O; Rathkolb B; Rozman J; Adamski J; Bekeredjian R; Busch DH; Graw J; Klingenspor M; Klopstock T; Neff F; Ollert M;Stoeger T; Yildrim AO; Eickelberg O; Wolf E; Wurst W; Fuchs H; Gailus-Durner V; de Angelis MH; Lufkin T; Stanton LW. 2014. Pleiotropic functions for transcription factor zscan10. PLoS One 9(8):e104568. PubMed: 25111779MGI: J:221010
- Kudo NR; Wassmann K; Anger M; Schuh M; Wirth KG; Xu H; Helmhart W; Kudo H; McKay M; Maro B; Ellenberg J; de Boer P; Nasmyth K. 2006. Resolution of chiasmata in oocytes requires separase-mediated proteolysis. Cell 126(1):135-46. PubMed: 16839882MGI: J:144684
- Lahmann I; Fabienke M; Henneberg B; Pabst O; Vauti F; Minge D; Illenberger S; Jockusch BM; Korte M; Arnold HH. 2008. The hnRNP and cytoskeletal protein raver1 contributes to synaptic plasticity. Exp Cell Res 314(5):1048-60. PubMed: 18061163MGI: J:137591
- Le Bin GC; Munoz-Descalzo S; Kurowski A; Leitch H; Lou X; Mansfield W; Etienne-Dumeau C; Grabole N; Mulas C; Niwa H; Hadjantonakis AK; Nichols J. 2014. Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst. Development 141(5):1001-10. PubMed: 24504341MGI: J:208425
- Lee WJ; Kraus P; Lufkin T. 2012. Endogenous tagging of the murine transcription factor Sox5 with hemaglutinin for functional studies. Transgenic Res 21(2):293-301. PubMed: 21732189MGI: J:183576
- Levin SI; Meisler MH. 2004. Floxed allele for conditional inactivation of the voltage-gated sodium channel Scn8a (Na(v)1.6). Genesis 39(4):234-9. PubMed: 15286995MGI: J:91696
- Li G; Zhou L; Zhu Y; Wang C; Sha S; Xian X; Ji Y; Liu G; Chen L. 2015. Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARgamma. Dis Model Mech 8(12):1615-24. PubMed: 26398946MGI: J:226846
- Li H; Wang D; Singh LS; Berk M; Tan H; Zhao Z; Steinmetz R; Kirmani K; Wei G; Xu Y. 2009. Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1. PLoS One 4(5):e5705. PubMed: 19479052MGI: J:149315
- Li J; Chen K; Zhu L; Pollard JW. 2006. Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice. Genesis 44(7):328-35. PubMed: 16823860MGI: J:110981
- Li X; Tripurani SK; James R; Pangas SA. 2012. Minimal fertility defects in mice deficient in oocyte-expressed Smad4. Biol Reprod 86(1):1-6. PubMed: 21900682MGI: J:185785
- Li Y; Yu S; Duncan T; Li Y; Liu P; Gene E; Cortes-Pena Y; Qian H; Dong L; Redmond TM. 2015. Mouse model of human RPE65 P25L hypomorph resembles wild type under normal light rearing but is fully resistant to acute light damage. Hum Mol Genet 24(15):4417-28. PubMed: 25972377MGI: J:223999
- Lin PP; Pandey MK; Jin F; Xiong S; Deavers M; Parant JM; Lozano G. 2008. EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model. Cancer Res 68(21):8968-75. PubMed: 18974141MGI: J:140636
- Malhotra R; Warne JP; Salas E; Xu AW; Debnath J. 2015. Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity. Autophagy 11(1):145-54. PubMed: 25585051MGI: J:232686
- Matsushita T; Wilcox WR; Chan YY; Kawanami A; Bukulmez H; Balmes G; Krejci P; Mekikian PB; Otani K; Yamaura I; Warman ML; Givol D; Murakami S. 2009. FGFR3 promotes synchondrosis closure and fusion of ossification centers through the MAPK pathway. Hum Mol Genet 18(2):227-40. PubMed: 18923003MGI: J:143273
- McMahon HE; Hashimoto O; Mellon PL; Shimasaki S. 2008. Oocyte-specific overexpression of mouse bone morphogenetic protein-15 leads to accelerated folliculogenesis and an early onset of acyclicity in transgenic mice. Endocrinology 149(6):2807-15. PubMed: 18308851MGI: J:136039
- Menon MB; Sawada A; Chaturvedi A; Mishra P; Schuster-Gossler K; Galla M; Schambach A; Gossler A; Forster R; Heuser M; Kotlyarov A; Kinoshita M; Gaestel M. 2014. Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis. PLoS Genet 10(8):e1004558. PubMed: 25122120MGI: J:223786
- Merscher S; Funke B; Epstein JA; Heyer J; Puech A; Lu MM; Xavier RJ; Demay MB; Russell RG; Factor S; Tokooya K; Jore BS; Lopez M; Pandita RK; Lia M; Carrion D; Xu H; Schorle H; Kobler JB; Scambler P; Wynshaw-Boris A; Skoultchi AI; Morrow BE; KucherlapatiR. 2001. TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell 104(4):619-29. PubMed: 11239417MGI: J:67796
- Miyoshi T; Maruhashi M; Van De Putte T; Kondoh H; Huylebroeck D; Higashi Y. 2006. Complementary expression pattern of Zfhx1 genes Sip1 and deltaEF1 in the mouse embryo and their genetic interaction revealed by compound mutants. Dev Dyn 235(7):1941-1952. PubMed: 16598713MGI: J:108819
- Mookherjee S; Hiriyanna S; Kaneshiro K; Li L; Li Y; Li W; Qian H; Li T; Khanna H; Colosi P; Swaroop A; Wu Z. 2015. Long-term rescue of cone photoreceptor degeneration in retinitis pigmentosa 2 (RP2)-knockout mice by gene replacement therapy. Hum Mol Genet 24(22):6446-58. PubMed: 26358772MGI: J:226494
- Muller JM; Deinhardt K; Rosewell I; Warren G; Shima DT. 2007. Targeted deletion of p97 (VCP/CDC48) in mouse results in early embryonic lethality. Biochem Biophys Res Commun 354(2):459-465. PubMed: 17239345MGI: J:118184
- Murakami S; Balmes G; McKinney S; Zhang Z; Givol D; de Crombrugghe B. 2004. Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. Genes Dev 18(3):290-305. PubMed: 14871928MGI: J:88286
- Murphy DJ; Junttila MR; Pouyet L; Karnezis A; Shchors K; Bui DA; Brown-Swigart L; Johnson L; Evan GI. 2008. Distinct thresholds govern Myc's biological output in vivo. Cancer Cell 14(6):447-57. PubMed: 19061836MGI: J:142030
- Neves P; Lampropoulou V; Calderon-Gomez E; Roch T; Stervbo U; Shen P; Kuhl AA; Loddenkemper C; Haury M; Nedospasov SA; Kaufmann SH; Steinhoff U; Calado DP; Fillatreau S. 2010. Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection. Immunity 33(5):777-90. PubMed: 21093317MGI: J:167006
- Nishizaki Y; Takagi T; Matsui F; Higashi Y. 2014. SIP1 expression patterns in brain investigated by generating a SIP1-EGFP reporter knock-in mouse. Genesis 52(1):56-67. PubMed: 24243579MGI: J:207850
- Nowell CS; Bredenkamp N; Tetelin S; Jin X; Tischner C; Vaidya H; Sheridan JM; Stenhouse FH; Heussen R; Smith AJ; Blackburn CC. 2011. Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet 7(11):e1002348. PubMed: 22072979MGI: J:177992
- Okano T; Xuan S; Kelley MW. 2011. Insulin-like growth factor signaling regulates the timing of sensory cell differentiation in the mouse cochlea. J Neurosci 31(49):18104-18. PubMed: 22159122MGI: J:178908
- Olson DP; Pulinilkunnil T; Cline GW; Shulman GI; Lowell BB. 2010. Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake. Proc Natl Acad Sci U S A 107(16):7598-603. PubMed: 20368432MGI: J:159285
- Pallerla SR; Lawrence R; Lewejohann L; Pan Y; Fischer T; Schlomann U; Zhang X; Esko JD; Grobe K. 2008. Altered heparan sulfate structure in mice with deleted NDST3 gene function. J Biol Chem 283(24):16885-94. PubMed: 18385133MGI: J:138557
- Pant V; Xiong S; Iwakuma T; Quintas-Cardama A; Lozano G. 2011. Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability. Proc Natl Acad Sci U S A 108(29):11995-2000. PubMed: 21730132MGI: J:174368
- Plaks V; Gershon E; Zeisel A; Jacob-Hirsch J; Neeman M; Winterhager E; Rechavi G; Domany E; Dekel N. 2014. Blastocyst implantation failure relates to impaired translational machinery gene expression. Reproduction 148(1):87-98. PubMed: 24700326MGI: J:213754
- Puech A; Saint-Jore B; Merscher S; Russell RG; Cherif D; Sirotkin H; Xu H; Factor S; Kucherlapati R; Skoultchi AI. 2000. Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region. Proc Natl Acad Sci U S A 97(18):10090-5. PubMed: 10963672MGI: J:64380
- Rana U; Liu Z; Kumar SN; Zhao B; Hu W; Bordas M; Cossette S; Szabo S; Foeckler J; Weiler H; Chrzanowska-Wodnicka M; Holtz ML; Misra RP; Salato V; North PE; Ramchandran R; Miao QR. 2016. Nogo-B receptor deficiency causes cerebral vasculature defects during embryonic development in mice. Dev Biol 410(2):190-201. PubMed: 26746789MGI: J:229464
- Schmidt JV; Levorse JM; Tilghman SM. 1999. Enhancer competition between H19 and Igf2 does not mediate their imprinting. Proc Natl Acad Sci U S A 96(17):9733-8. PubMed: 10449763MGI: J:57113
- Schoeller EL; Clark DD; Dey S; Cao NV; Semaan SJ; Chao LW; Kauffman AS; Stowers L; Mellon PL. 2016. Bmal1 Is Required for Normal Reproductive Behaviors in Male Mice. Endocrinology 157(12):4914-4929. PubMed: 27704948MGI: J:240666
- Schrode N; Saiz N; Di Talia S; Hadjantonakis AK. 2014. GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. Dev Cell 29(4):454-67. PubMed: 24835466MGI: J:213580
- Semjonous NM; Sherlock M; Jeyasuria P; Parker KL; Walker EA; Stewart PM; Lavery GG. 2011. Hexose-6-phosphate dehydrogenase contributes to skeletal muscle homeostasis independent of 11beta-hydroxysteroid dehydrogenase type 1. Endocrinology 152(1):93-102. PubMed: 21106871MGI: J:189132
- Shin JY; Fitzpatrick GV; Higgins MJ. 2008. Two distinct mechanisms of silencing by the KvDMR1 imprinting control region. EMBO J 27(1):168-78. PubMed: 18079696MGI: J:130529
- Silk AD; Holland AJ; Cleveland DW. 2009. Requirements for NuMA in maintenance and establishment of mammalian spindle poles. J Cell Biol 184(5):677-90. PubMed: 19255246MGI: J:146214
- Simpson TI; Pratt T; Mason JO; Price DJ. 2009. Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice. Neural Dev 4:19. PubMed: 19500363MGI: J:151427
- Solc P; Baran V; Mayer A; Bohmova T; Panenkova-Havlova G; Saskova A; Schultz RM; Motlik J. 2012. Aurora kinase A drives MTOC biogenesis but does not trigger resumption of meiosis in mouse oocytes matured in vivo. Biol Reprod 87(4):85. PubMed: 22837479MGI: J:192498
- Stephenson RO; Yamanaka Y; Rossant J. 2010. Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin. Development 137(20):3383-91. PubMed: 20826529MGI: J:165812
- Su X; Paris M; Gi YJ; Tsai KY; Cho MS; Lin YL; Biernaskie JA; Sinha S; Prives C; Pevny LH; Miller FD; Flores ER. 2009. TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell 5(1):64-75. PubMed: 19570515MGI: J:151638
- Sultana A; Nakaya N; Dong L; Abu-Asab M; Qian H; Tomarev SI. 2014. Deletion of olfactomedin 2 induces changes in the AMPA receptor complex and impairs visual, olfactory, and motor functions in mice. Exp Neurol 261:802-11. PubMed: 25218043MGI: J:217902
- Tachibana-Konwalski K; Godwin J; van der Weyden L; Champion L; Kudo NR; Adams DJ; Nasmyth K. 2010. Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes. Genes Dev 24(22):2505-16. PubMed: 20971813MGI: J:166151
- Tao KP; Fong SW; Lu Z; Ching YP; Chan KW; Chan SY. 2011. TSPYL2 Is Important for G1 Checkpoint Maintenance upon DNA Damage. PLoS One 6(6):e21602. PubMed: 21738728MGI: J:174549
- Valluet A; Hmitou I; Davis S; Druillennec S; Larcher M; Laroche S; Eychene A. 2010. B-raf alternative splicing is dispensable for development but required for learning and memory associated with the hippocampus in the adult mouse. PLoS One 5(12):e15272. PubMed: 21203559MGI: J:168330
- Venkatanarayan A; Raulji P; Norton W; Chakravarti D; Coarfa C; Su X; Sandur SK; Ramirez MS; Lee J; Kingsley CV; Sananikone EF; Rajapakshe K; Naff K; Parker-Thornburg J; Bankson JA; Tsai KY; Gunaratne PH; Flores ER. 2015. IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. Nature 517(7536):626-30. PubMed: 25409149MGI: J:218385
- Wang C; Ruther U; Wang B. 2007. The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. Dev Biol 305(2):460-9. PubMed: 17400206MGI: J:121609
- Williams SA; Stanley P. 2011. Premature ovarian failure in mice with oocytes lacking core 1-derived O-glycans and complex N-glycans. Endocrinology 152(3):1057-66. PubMed: 21239444MGI: J:173879
- Williams SA; Xia L; Cummings RD; McEver RP; Stanley P. 2007. Fertilization in mouse does not require terminal galactose or N-acetylglucosamine on the zona pellucida glycans. J Cell Sci 120(Pt 8):1341-9. PubMed: 17374637MGI: J:122012
- Winger Q; Huang J; Auman HJ; Lewandoski M; Williams T. 2006. Analysis of transcription factor AP-2 expression and function during mouse preimplantation development. Biol Reprod 75(3):324-33. PubMed: 16672719MGI: J:113442
- Xiao Y; Ma H; Wan P; Qin D; Wang X; Zhang X; Xiang Y; Liu W; Chen J; Yi Z; Li L. 2017. Trp-Asp (WD) Repeat Domain 1 Is Essential for Mouse Peri-implantation Development and Regulates Cofilin Phosphorylation. J Biol Chem 292(4):1438-1448. PubMed: 27994054MGI: J:239230
- Xu X; Yang D; Ding JH; Wang W; Chu PH; Dalton ND; Wang HY; Bermingham JR Jr; Ye Z; Liu F; Rosenfeld MG; Manley JL; Ross J Jr; Chen J; Xiao RP; Cheng H; Fu XD. 2005. ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell 120(1):59-72. PubMed: 15652482MGI: J:96039
- Yamben IF; Rachel RA; Shatadal S; Copeland NG; Jenkins NA; Warming S; Griep AE. 2013. Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse. Dev Biol 384(1):41-52. PubMed: 24095903MGI: J:204591
- Zhang CX; Zhang Q; Xie YY; He XY; Xiang C; Hou XS; Zhou Y; Chen L; Zhang GX; Liu G. 2017. Mouse Double Minute 2 Actively Suppresses p53 Activity in Oocytes during Mouse Folliculogenesis. Am J Pathol 187(2):339-351. PubMed: 27912078MGI: J:240039
- Zheng K; Xiol J; Reuter M; Eckardt S; Leu NA; McLaughlin KJ; Stark A; Sachidanandam R; Pillai RS; Wang PJ. 2010. Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway. Proc Natl Acad Sci U S A :. PubMed: 20534472MGI: J:161125
- de Vries WN; Binns LT; Fancher KS; Dean J; Moore R; Kemler R; Knowles BB. 2000. Expression of Cre recombinase in mouse oocytes: a means to study maternal effect genes. Genesis 26(2):110-2. PubMed: 10686600MGI: J:67903