FVB/N-Tg(Zp3-cre)3Mrt/J

Stock number: 003377
Product name: Zp3-cre
Research areas: Research Tools

Description

These Zp3-cre mice express a transgene containing cre with the mouse zona pellucida 3 (Zp3) promoter.

Detailed description

The strain originated on an FVB/N background and is currently on the same background. The investigator maintains the strain by breeding hemizygotes. Homozygotes are subfertile. This is a transgenic line in which cre expression is controlled by the regulatory sequences from the mouse zona pellucida 3 (Zp3) gene, which is normally expressed exclusively in the growing oocyte prior to the completion of the first meiotic division. This strain would be useful for deleting a floxed sequence specifically in the female germ line.

Development

A CreZp3 construct was injected into FVB/N zygotes to produce the founder line. The strain originated on an FVB/N background and is currently on the same background. Female homozygotes are subfertile.

Allele

Symbol: Tg(Zp3-cre)3Mrt
Name: transgene insertion 3, Gail R Martin
MGI accession ID: MGI:2176052
Generation method: Transgenic
Attributes: Recombinase-expressing
Marker symbol: Tg(Zp3-cre)3Mrt
Marker name: transgene insertion 3, Gail R Martin
Chromosome: UN
Strain of origin: FVB/N
Expressed genes: cre,cre recombinase,bacteriophage P1
Site of expression: prior to first meiotic division
Molecular note: This transgene expresses NLS-Cre recombinase under the control of a mouse zona pellucida 3 promoter. This promoter is active in oocytes. No expression was detected in somatic tissues.
General note: Homozygous transgenic mice are viable and fertile.