NOD.B6-Tg(HLA-B27)30-4Trg/DvsJ

Stock number: 003354
Product name: HLA-B27
Research areas: Immunology, Inflammation and Autoimmunity Research

Detailed description

These transgenic mice express human HLA-B27 on a NOD background, but show no acceleration of type 1 diabetes and are significantly protected from disease.

Development

The Tg(HLA-B27)30-4Trg allele was generated by injection into the male pronucleus of C57BL/6J fertilized eggs (Taurog et al., 1988). This allele was imported into The Jackson Laboratory and backcrossed onto NOD/Lt until N9 and was then mated to homozygosity.

Allele

Symbol: Tg(HLA-B27)30-4Trg
Name: transgene insertion 30-4, Joel D Taurog
MGI accession ID: MGI:2159095
Generation method: Transgenic
Attributes: Inserted expressed sequence; Humanized sequence
Synonyms: HLA-B27; Tg(HLA*B27)30-4Trg; Tg(HLA-B)30-4Trg; Tg(HLA-B27)30-4Trg
Marker symbol: Tg(HLA-B27)30-4Trg
Marker name: transgene insertion 30-4, Joel D Taurog
Marker synonyms: HLA-B27; Tg(HLA*B27)30-4Trg; Tg(HLA-B)30-4Trg
Chromosome: UN
Strain of origin: C57BL/6J
Expressed genes: HLA-B,major histocompatibility complex, class I, B,human
Molecular note: A transgene containing the human HLA-B allele, HLA-B27, was shown to be expressed in spleen cells of mice carrying the transgene.