These mice express a transgene containing the beta-galactosidase gene under control of the tissue inhibitor of metalloproteinase 3 (Timp3) promoter.
Dr. Jean Bennett, Scheie Eye Institute
Genetic Background | Generation |
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Allele Type |
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Transgenic (Reporter) |
These transgenic mice show no phenotypic defects. LacZ expression is observed in the eye, specifically in the corneal endothelium and ganglion cell layer. LacZ expression is also observed in the kidney, choroid plexus, testes and ovaries, gingiva, bone and the hair follicles of the skin. Transgene expression is developmentally regulated.
Expressed Gene | lacZ, beta-galactosidase, E. coli |
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Site of Expression | Eye, specifically in the corneal endothelium and ganglion cell layer, kidney, choroid plexus, testes and ovaries,gingiva, bone and the hair follicles of the skin. |
Allele Name | transgene insertion 7, Jean Bennett |
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Allele Type | Transgenic (Reporter) |
Allele Synonym(s) | |
Gene Symbol and Name | Tg(TIMP3-lacZ)7Jeb, transgene insertion 7, Jean Bennett |
Gene Synonym(s) | |
Promoter | TIMP3, TIMP metallopeptidase inhibitor 3, human |
Expressed Gene | lacZ, beta-galactosidase, E. coli |
Site of Expression | Eye, specifically in the corneal endothelium and ganglion cell layer, kidney, choroid plexus, testes and ovaries,gingiva, bone and the hair follicles of the skin. |
Strain of Origin | Not Applicable |
Chromosome | UN |
General Note | Transgenic mice on a B6;SWJ background show no phenotypic defects. lacZ expression is observed in the eye, specifically in the corneal endothelium and ganglion cell layer. lacZ expression is also observed in the kidney, choroid plexus, testes and ovaries, gingiva, bone and the hair follicles of the skin. Transgene expression is developmentally regulated. |
Molecular Note | The transgene contains the beta-galactosidase gene under control of the tissue inhibitor of metalloproteinase 3 (Timp3) promoter. |
When maintaining a live colony, these mice can be bred as homozygotes.
When using the B6;SWJ-Tg(TIMP3-lacZ)7Jeb/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #003299 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Hemizygous or Non carrierfor Tg(TIMP3-lacZ)7Jeb |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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