B6;SWJ-Tg(TIMP3-lacZ)7Jeb/J

Stock number: 003299
Research areas: Research Tools

Description

These mice express a transgene containing the beta-galactosidase gene under control of the tissue inhibitor of metalloproteinase 3 (Timp3) promoter.

Detailed description

These transgenic mice show no phenotypic defects. LacZ expression is observed in the eye, specifically in the corneal endothelium and ganglion cell layer. LacZ expression is also observed in the kidney, choroid plexus, testes and ovaries, gingiva, bone and the hair follicles of the skin. Transgene expression is developmentally regulated.

Allele

Symbol: Tg(TIMP3-lacZ)7Jeb
Name: transgene insertion 7, Jean Bennett
MGI accession ID: MGI:3056798
Generation method: Transgenic
Attributes: Reporter
Marker symbol: Tg(TIMP3-lacZ)7Jeb
Marker name: transgene insertion 7, Jean Bennett
Chromosome: UN
Strain of origin: Not Applicable
Expressed genes: lacZ,beta-galactosidase,E. coli
Site of expression: Eye, specifically in the corneal endothelium and ganglion cell layer, kidney, choroid plexus, testes and ovaries,gingiva, bone and the hair follicles of the skin.
Molecular note: The transgene contains the beta-galactosidase gene under control of the tissue inhibitor of metalloproteinase 3 (Timp3) promoter.
General note: Transgenic mice on a B6;SWJ background show no phenotypic defects. lacZ expression is observed in the eye, specifically in the corneal endothelium and ganglion cell layer. lacZ expression is also observed in the kidney, choroid plexus, testes and ovaries, gingiva, bone and the hair follicles of the skin. Transgene expression is developmentally regulated.