These Fshb knock-out mice exhibit small testes, reduced sperm number and sperm motility. They are suitable for use in applications related to studies of human diseases involving the gonadotropin signal transduction pathway.
Dr. T. R. Kumar, University of Kansas
Males carrying the targeted mutation are fertile, have small testes, reduced sperm number and sperm motility. Homozygous mutant females are infertile due to a preantral stage block in ovarian folliculogenesis. Heterozygotes are fertile.
|Allele Name||targeted mutation 1, Martin M Matzuk|
|Allele Type||Targeted (Null/Knockout)|
|Allele Synonym(s)||fshbm1; FSHbeta-; FSHbetaKO|
|Gene Symbol and Name||Fshb, follicle stimulating hormone beta|
|Strain of Origin||129S7/SvEvBrd-Hprtb-m2|
|Molecular Note||An HPRT minigene replaced a genomic fragment containing exons 1, 2 and part of 3. Northern blot analysis on RNA derived from pituitary of homozygous mice demonstrated that no detectable transcript was produced from thia allele. Radioimmunoasays on serum from homozygous mice confirmed that no functional protein was expressed from this allele.|
|Mutations Made By|| |
Dr. T. Kumar, University of Kansas
Homozygous females are infertile. Heterozygous females can be bred with homozygous males. The expected coat colors are black and agouti.
When using the FSH KO mouse strain in a publication, please cite the originating article(s) and include JAX stock #003283 in your Materials and Methods section.