B6;129P2-Hbb-b1^tm1Unc Hbb-b2^tm1Unc/J

Stock number: 003253
Product name: Β-thalassemic
Research areas: Hematological Research

Description

These mice carry a double knock-out of the Hbb-b1 and Hbb-b2 adult Β-globin genes with a phenotype similar to Cooley anemia in humans.

Detailed description

Homozygous mice die perinatally. Heterozygous mice show "characteristics typical of severe thalassemia" and are fertile.

Allele

Symbol: Hbb-b2^tm1Unc
Name: targeted mutation 1, University of North Carolina
MGI accession ID: MGI:1857296
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Hbb-b2
Marker name: hemoglobin, beta adult minor chain
Chromosome: 7
Strain of origin: 129P2/OlaHsd
Molecular note: Hbb-b1 and Hbb-b2 were deleted using a two-step "plug and socket" method which leaves an hprt gene integrated in the genome.

Allele

Symbol: Hbb-b1^tm1Unc
Name: targeted mutation 1, University of North Carolina
MGI accession ID: MGI:1857295
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Hbb-b1
Marker name: hemoglobin, beta adult major chain
Chromosome: 7
Strain of origin: 129P2/OlaHsd
Molecular note: Hbb-b1 and Hbb-b2 were deleted using a two-step "plug and socket" method which leaves an hprt gene integrated in the genome.