JAX
Mouse Strain Datasheet - 003245
B6.129S7-Il1r1tm1Imx/J
Also Known As: Il1r1-
IL-1 receptor KO mice exhibit altered innate immune and inflammatory responses and show multiple effects on physiological systems and behavior.
Donating Investigator
Dr. Jacques Peschon, Amgen
Genetic overview
| Genetic Background | Generation |
|---|---|
|
C57BL/6 |
N5+N3F8
|
Il1r1tm1Imx
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Il1r1 | interleukin 1 receptor, type I |
Research Applications
- Cancer Research
- Immunology, Inflammation and Autoimmunity Research
Detailed Description
Interleukin 1 receptor, type I, is a receptor for interleukin 1 (IL1), which affects many cytokine induced immune and inflammatory responses. Mice homozygous for the Il1rtm1Imx targeted mutation therefore fail to respond to IL1 and exhibit an altered immune response to many different target proteins. Some effects seen from knocking out this receptor include defective responses to certain inflammatory agents such as turpentine and altered response to various pathogenic organisms such as S. aureus and C. pneumoniae.
Other observed effects include enhanced glucose homeostasis, enhanced insulin sensitivity of adipose tissue, reduction in diet-induced systemic atherosclerosis, improved restoration of normal skin architecture in wounds, increased incidence of acute convulsive seizures induced by pentylenetetrazole, and a decrease in anxiety-related behaviors.
Development
A null mutation in Il1r1 was generated by homologous recombination in 129/SvEv AB1 ES cells using a replacement vector in which a 2.4 kb EcoR1-Pst1 fragment encompassing two exons was replaced with a PGKneo cassette. Targeted mutant mice were backcrossed 5 times to C57BL/6 prior to importation (see SNP note below).
A 48 SNP (single nucleotide polymorphism) panel analysis, with 43 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. One the 43 markers on Chromosome 8 was segregating with 129. Also, 2 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository were on a mixed C57BL/6J ; C57BL/6N genetic background.
Control Suggestions
Selected References
- Glaccum MB; Stocking KL; Charrier K; Smith JL; Willis CR; Maliszewski C ; Livingston DJ ; Peschon JJ ; Morrissey PJ. 1997. Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. J Immunol 159(7):3364-71. PubMed: 9317135MGI: J:43088
Il1r1tm1Imx
Allele Symbol: Il1r1tm1Imx
| Allele Name | targeted mutation 1, Immunex Research and Development Corporation |
|---|---|
| Allele Type | Targeted (Null/Knockout) |
| Allele Synonym(s) | IL-1R1-; IL-1R-; IL-1RI KO; IL-R1-; Il1r1tm1jmx; Il1rtm1Imx; RIko |
| Gene Symbol and Name | Il1r1, interleukin 1 receptor, type I |
| Gene Synonym(s) | CD121A; CD121a; D2S1473; IL-1 receptor alpha chain; IL-1R-alpha; IL-1R1; IL-iR; IL1R; IL1RA; Il1r-1; Il1r-1; P80 |
| Strain of Origin | 129S7/SvEvBrd-Hprt<+> |
| Chromosome | 1 |
| Molecular Note | A neomycin resistance cassette replaced two exons of the gene, which encode amino acids 4 - 225 of the mature protein. |
| Mutations Made By | Dr. Jacques Peschon, Amgen |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
Genotype: Il1r1tm1Imx related
- Cancer Research
- Growth Factors/Receptors/Cytokines
- Immunology, Inflammation and Autoimmunity Research
- Growth Factors/Receptors/Cytokines
Mammalian Phenotype Terms by Genotype
Genotype: Il1r1tm1Imx/Il1r1tm1Imx
B6.129S7-Il1r1tm1Imx
immune system phenotype
- immune system phenotype
- mice co-housed with wild-type mice do not affect the susceptibility to induced colitis of wild-type mice (MGI Ref ID J:173245)
Genotype: Il1r1tm1Imx/Il1r1tm1Imx
B6.129S7-Il1r1tm1Imx/J
mortality/aging
- increased susceptibility to bacterial infection induced morbidity/mortality
- following S. aureus infection (MGI Ref ID J:125570)
nervous system phenotype
- abnormal nervous system electrophysiology
- following administration of kainate, Purkinje cells fail to exhibit an increase in firing rate unlike wild-type cells (MGI Ref ID J:145169)
immune system phenotype
- decreased circulating interleukin-18 level
- 24 hours following S. aureus infection (MGI Ref ID J:125570)
- decreased circulating interleukin-6 level
- 4 and 24 hours following S. aureus infection (MGI Ref ID J:125570)
- decreased interleukin-6 secretion
- decreased tumor necrosis factor secretion
- in spleen cells stimulated with formalin-killed S. aureus infection (MGI Ref ID J:125570)
- increased circulating interleukin-1 beta level
- 96 hours following S. aureus infection (MGI Ref ID J:125570)
- increased circulating interleukin-18 level
- 96 hours following S. aureus infection (MGI Ref ID J:125570)
- increased susceptibility to bacterial infection
- following S. aureus infection, mice exhibit severe septicemia, increased weight loss, increased frequency and severity of arthritis, increased bacterial load, and decreased survival compared with wild-type mice (MGI Ref ID J:125570)
- increased susceptibility to bacterial infection induced morbidity/mortality
- following S. aureus infection (MGI Ref ID J:125570)
- increased susceptibility to induced arthritis
- following S. aureus infection (MGI Ref ID J:125570)
- sepsis
- following S. aureus infection (MGI Ref ID J:125570)
homeostasis/metabolism phenotype
- abnormal vascular wound healing
- following carotid ligation, mice exhibit a 19-fold reduction in neointima/media area, 3.4-fold increase in lumen area, and decrease in total vessel area compared with wild-type mice (MGI Ref ID J:107324)
- neointima formation following carotid ligation is disrupted to a greater extent when null mice transplanted with null bone marrow compared when null mice are receive wild-type bone marrow or wild-type mice receive null bone marrow (MGI Ref ID J:107324)
- decreased circulating interleukin-18 level
- 24 hours following S. aureus infection (MGI Ref ID J:125570)
- decreased circulating interleukin-6 level
- 4 and 24 hours following S. aureus infection (MGI Ref ID J:125570)
- decreased transforming growth factor level
- within wound fluids on day 1 of wound healing (MGI Ref ID J:148779)
- enhanced wound healing
- after wound healing, mice exhibit decreased scar width and depth compared with wild-type mice (MGI Ref ID J:148779)
- deep tissue wounds exhibit 3-fold less fibrosis compared to in wild-type mice (MGI Ref ID J:148779)
- however, mice exhibit normal cellular infiltration and tensile strength of skin wounds (MGI Ref ID J:148779)
- impaired glucose tolerance
- following glucose challenge, older mice exhibit impaired plasma glucose elimination compared with wild-type mice (MGI Ref ID J:108634)
- increased circulating insulin level
- 2-fold in 9 and 11 month old mice (MGI Ref ID J:108634)
- increased circulating insulin-like growth factor I level
- in older mice (MGI Ref ID J:108634)
- increased circulating interleukin-1 beta level
- 96 hours following S. aureus infection (MGI Ref ID J:125570)
- increased circulating interleukin-18 level
- 96 hours following S. aureus infection (MGI Ref ID J:125570)
- increased circulating leptin level
- 2-fold in 9 and 11 month old mice (MGI Ref ID J:108634)
- increased respiratory quotient
- during the first half of the dark cycle (MGI Ref ID J:108634)
- insulin resistance
- in older mice (MGI Ref ID J:108634)
growth/size/body region phenotype
- abnormal lean body mass
- older mice exhibit a decrease in percentage lean body mass but an increase in absolute lean body mass compared with wild-type mice (MGI Ref ID J:108634)
- increased body length
- in older mice (MGI Ref ID J:108634)
- increased body mass index
- in older mice (MGI Ref ID J:108634)
- increased body weight
- after 5 to 6 months (MGI Ref ID J:108634)
- increased growth rate
- in older mice (MGI Ref ID J:108634)
- increased susceptibility to age related obesity
- (MGI Ref ID J:108634)
- weight loss
- following S. aureus infection (MGI Ref ID J:125570)
adipose tissue phenotype
- increased abdominal fat pad weight
- at 19 months, intra-abdominal fat mass is increased 1.5- to 1.7-fold compared with wild-type mice (MGI Ref ID J:108634)
- increased gonadal fat pad weight
- in older mice (MGI Ref ID J:108634)
- increased inguinal fat pad weight
- in older mice (MGI Ref ID J:108634)
- increased mesenteric fat pad weight
- in older mice (MGI Ref ID J:108634)
- increased percent body fat/body weight
- in older mice (MGI Ref ID J:108634)
- increased retroperitoneal fat pad weight
- in older mice (MGI Ref ID J:108634)
- increased total body fat amount
skeleton phenotype
- increased susceptibility to induced arthritis
- following S. aureus infection (MGI Ref ID J:125570)
behavior/neurological phenotype
- abnormal food intake
- preobese mice exhibit mild leptin resistance compared with wild-type mice (MGI Ref ID J:108634)
- decreased anxiety-related response
- mice exhibit increased latency to enter into the dark chamber in a light/dark test compared with wild-type mice (MGI Ref ID J:150445)
- mice exhibit reduced latency to drink in a novelty-induced hypophagia test compared with wild-type mice (MGI Ref ID J:150445)
- mice spend more time in the open arms of an elevated plus maze compared with wild-type mice (MGI Ref ID J:150445)
- enhanced contextual conditioning behavior
- (MGI Ref ID J:150445)
- hypoactivity
- during the dark phase at 4 months (MGI Ref ID J:108634)
liver/biliary system phenotype
- increased liver weight
- in older mice (MGI Ref ID J:108634)
cardiovascular system phenotype
- abnormal vascular wound healing
- following carotid ligation, mice exhibit a 19-fold reduction in neointima/media area, 3.4-fold increase in lumen area, and decrease in total vessel area compared with wild-type mice (MGI Ref ID J:107324)
- neointima formation following carotid ligation is disrupted to a greater extent when null mice transplanted with null bone marrow compared when null mice are receive wild-type bone marrow or wild-type mice receive null bone marrow (MGI Ref ID J:107324)
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Il1r1tm1Imx/Il1r1tm1Imx
involves: 129S7/SvEvBrd * C57BL/6
homeostasis/metabolism phenotype
- abnormal response/metabolism to endogenous compounds
- however, behavioral response to LPS treatment is normal (MGI Ref ID J:112148)
- mice treated with IL1b, either intraperitoneally or intracerebroventricularly, fail to exhibit a decrease in social exploration, immobility, decrease in body weight, or reduced food intake compared with similarly treated wild-type mice (MGI Ref ID J:112148)
- pretreatment with TNFbp attenuates depressive effect of LPS unlike in similarly treated wild-type mice (MGI Ref ID J:112148)
- decreased blood urea nitrogen level
- following ischemic/reperfusion injury, mice exhibit reduced blood urea nitrogen levels at 48 and 72 hours compared with wild-type mice (MGI Ref ID J:112999)
- decreased circulating creatinine level
- following ischemic/reperfusion injury, mice exhibit reduced serum creatinine levels at 48 and 72 hours compared with wild-type mice (MGI Ref ID J:112999)
- decreased susceptibility to kidney reperfusion injury
immune system phenotype
- abnormal neutrophil physiology
- following ischemic/reperfusion injury, mice exhibit reduced polymorphonuclear leukocyte infiltration compared with wild-type mice (MGI Ref ID J:112999)
- decreased susceptibility to experimental autoimmune uveoretinitis
- following reverse passive Arthus reaction to induce uveitis, mice exhibit reduced cellular infiltration into the anterior and posterior segments compared with wild-type mice (MGI Ref ID J:115094)
renal/urinary system phenotype
- decreased susceptibility to kidney reperfusion injury
growth/size/body region phenotype
- increased body weight
- in some experiments (MGI Ref ID J:112148)
hematopoietic system phenotype
- abnormal neutrophil physiology
- following ischemic/reperfusion injury, mice exhibit reduced polymorphonuclear leukocyte infiltration compared with wild-type mice (MGI Ref ID J:112999)
Genotype: Il1r1tm1Imx/Il1r1tm1Imx
involves: 129 * C57BL/6
homeostasis/metabolism phenotype
- decreased circulating interleukin-6 level
- no IL-6 is detected in sera of mice injected with IL-1alpha (MGI Ref ID J:43088)
immune system phenotype
- decreased circulating interleukin-6 level
- no IL-6 is detected in sera of mice injected with IL-1alpha (MGI Ref ID J:43088)
- increased susceptibility to bacterial infection
- mice have 3 log greater bacterial penetration of the dental pulp eight days after bacterial innoculation (MGI Ref ID J:58851)
- osteomyelitis
skeleton phenotype
- dental pulp necrosis
- complete necrosis of the dental pulp is observed by 21 days after inoculation compared to control mice that still have intact dental pulp at 38 days post-innoculation (MGI Ref ID J:58851)
- mice have significantly higher necrosis scores of the dental pulp seven days after bacterial inoculation (MGI Ref ID J:58851)
- increased bone resorption
- osteomyelitis
craniofacial phenotype
- dental pulp necrosis
- complete necrosis of the dental pulp is observed by 21 days after inoculation compared to control mice that still have intact dental pulp at 38 days post-innoculation (MGI Ref ID J:58851)
- mice have significantly higher necrosis scores of the dental pulp seven days after bacterial inoculation (MGI Ref ID J:58851)
growth/size/body region phenotype
- dental pulp necrosis
- complete necrosis of the dental pulp is observed by 21 days after inoculation compared to control mice that still have intact dental pulp at 38 days post-innoculation (MGI Ref ID J:58851)
- mice have significantly higher necrosis scores of the dental pulp seven days after bacterial inoculation (MGI Ref ID J:58851)
Genotype: Il1r1tm1Imx/Il1r1tm1Imx
involves: 129S7/SvEvBrd
skeleton phenotype
- delayed tooth eruption
- mice exhibit delayed eruption of mandibular and maxillary incisors and molars compared with wild-type mice (MGI Ref ID J:103141)
craniofacial phenotype
- delayed tooth eruption
- mice exhibit delayed eruption of mandibular and maxillary incisors and molars compared with wild-type mice (MGI Ref ID J:103141)
immune system phenotype
- abnormal neutrophil physiology
- neutrophile response to monosodium urate injected into the peritoneal cavity is reduced 85% relative to controls (MGI Ref ID J:113110)
hematopoietic system phenotype
- abnormal neutrophil physiology
- neutrophile response to monosodium urate injected into the peritoneal cavity is reduced 85% relative to controls (MGI Ref ID J:113110)
growth/size/body region phenotype
- delayed tooth eruption
- mice exhibit delayed eruption of mandibular and maxillary incisors and molars compared with wild-type mice (MGI Ref ID J:103141)
References
- Glaccum MB; Stocking KL; Charrier K; Smith JL; Willis CR; Maliszewski C ; Livingston DJ ; Peschon JJ ; Morrissey PJ. 1997. Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. J Immunol 159(7):3364-71. PubMed: 9317135MGI: J:43088
Additional - Il1r1tm1Imx related
- Abcouwer SF; Norman J; Fink G; Carter G; Lustig RJ; Souba WW. 1996. Tissue-specific regulation of glutamine synthetase gene expression in acute pancreatitis is confirmed by using interleukin-1 receptor knockout mice. Surgery 120(2):255-63; discussion 263-4. PubMed: 8751591MGI: J:114173
- Abdalla H; Srinivasan L; Shah S; Mayer-Barber KD; Sher A; Sutterwala FS; Briken V. 2012. Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1beta and IL-18 secretion but not to pyroptosis. PLoS One 7(7):e40722. PubMed: 22911706MGI: J:189888
- Alexander MR; Moehle CW; Johnson JL; Yang Z; Lee JK; Jackson CL; Owens GK. 2012. Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice. J Clin Invest 122(1):70-9. PubMed: 22201681MGI: J:184390
- Allen RG; Lafuse WP; Powell ND; Webster Marketon JI; Stiner-Jones LM; Sheridan JF; Bailey MT. 2012. Stressor-Induced Increase in Microbicidal Activity of Splenic Macrophages Is Dependent upon Peroxynitrite Production. Infect Immun 80(10):3429-37. PubMed: 22825446MGI: J:187596
- Andoh T; Kishi H; Motoki K; Nakanishi K; Kuraishi Y; Muraguchi A. 2008. Protective effect of IL-18 on kainate- and IL-1beta-induced cerebellar ataxia in mice. J Immunol 180(4):2322-8. PubMed: 18250441MGI: J:131996
- Andre R; Moggs JG; Kimber I; Rothwell NJ; Pinteaux E. 2006. Gene regulation by IL-1beta independent of IL-1R1 in the mouse brain. Glia 53(5):477-83. PubMed: 16358337MGI: J:156138
- Babcock AA; Toft-Hansen H; Owens T. 2008. Signaling through MyD88 regulates leukocyte recruitment after brain injury. J Immunol 181(9):6481-90. PubMed: 18941239MGI: J:140719
- Baccarella A; Fontana MF; Chen EC; Kim CC. 2013. Toll-like receptor 7 mediates early innate immune responses to malaria. Infect Immun 81(12):4431-42. PubMed: 24042114MGI: J:202330
- Baracchi F; Opp MR. 2008. Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1 beta receptor 1 and tumor necrosis factor-alpha receptor 1. Brain Behav Immun 22(6):982-93. PubMed: 18329246MGI: J:137505
- Basu A; Krady JK; O'Malley M; Styren SD; DeKosky ST; Levison SW. 2002. The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury. J Neurosci 22(14):6071-82. PubMed: 12122068MGI: J:124246
- Basu A; Lazovic J; Krady JK; Mauger DT; Rothstein RP; Smith MB; Levison SW. 2005. Interleukin-1 and the interleukin-1 type 1 receptor are essential for the progressive neurodegeneration that ensues subsequent to a mild hypoxic/ischemic injury. J Cereb Blood Flow Metab 25(1):17-29. PubMed: 15678109MGI: J:105286
- Basu R; Whitley SK; Bhaumik S; Zindl CL; Schoeb TR; Benveniste EN; Pear WS; Hatton RD; Weaver CT. 2015. IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Nat Immunol 16(3):286-95. PubMed: 25642823MGI: J:244399
- Beaulieu LM; Lin E; Mick E; Koupenova M; Weinberg EO; Kramer CD; Genco CA; Tanriverdi K; Larson MG; Benjamin EJ; Freedman JE. 2014. Interleukin 1 receptor 1 and interleukin 1beta regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans. Arterioscler Thromb Vasc Biol 34(3):552-64. PubMed: 24458711MGI: J:222911
- Bettenworth D; Buyse M; Bohm M; Mennigen R; Czorniak I; Kannengiesser K; Brzoska T; Luger TA; Kucharzik T; Domschke W; Maaser C; Lugering A. 2011. The tripeptide KdPT protects from intestinal inflammation and maintains intestinal barrier function. Am J Pathol 179(3):1230-42. PubMed: 21741932MGI: J:176323
- Binstadt BA; Patel PR; Alencar H; Nigrovic PA; Lee DM; Mahmood U; Weissleder R; Mathis D; Benoist C. 2006. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 7(3):284-92. PubMed: 16444258MGI: J:112604
- Bluthe RM; Laye S; Michaud B; Combe C; Dantzer R; Parnet P. 2000. Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behaviour: a study with interleukin-1 type I receptor-deficient mice. Eur J Neurosci 12(12):4447-56. PubMed: 11122355MGI: J:112148
- Boettcher S; Ziegler P; Schmid MA; Takizawa H; van Rooijen N; Kopf M; Heikenwalder M; Manz MG. 2012. Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells. J Immunol 188(12):5824-8. PubMed: 22586037MGI: J:188869
- Bollampalli VP; Harumi Yamashiro L; Feng X; Bierschenk D; Gao Y; Blom H; Henriques-Normark B; Nylen S; Rothfuchs AG. 2015. BCG Skin Infection Triggers IL-1R-MyD88-Dependent Migration of EpCAMlow CD11bhigh Skin Dendritic cells to Draining Lymph Node During CD4+ T-Cell Priming. PLoS Pathog 11(10):e1005206. PubMed: 26440518MGI: J:246033
- Bonnet MC; Preukschat D; Welz PS; van Loo G; Ermolaeva MA; Bloch W; Haase I; Pasparakis M. 2011. The Adaptor Protein FADD Protects Epidermal Keratinocytes from Necroptosis In Vivo and Prevents Skin Inflammation. Immunity 35(4):572-82. PubMed: 22000287MGI: J:177639
- Brinster C; Shevach EM. 2008. Costimulatory effects of IL-1 on the expansion/differentiation of CD4+CD25+Foxp3+ and CD4+CD25+Foxp3- T cells. J Leukoc Biol 84(2):480-7. PubMed: 18477692MGI: J:138445
- Brito BE; O'Rourke LM; Pan Y; Anglin J; Planck SR; Rosenbaum JT. 1999. IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis. Invest Ophthalmol Vis Sci 40(11):2583-9. PubMed: 10509653MGI: J:115094
- Broide DH; Campbell K; Gifford T; Sriramarao P. 2000. Inhibition of eosinophilic inflammation in allergen-challenged, IL-1 receptor type 1-deficient mice is associated with reduced eosinophil rolling and adhesion on vascular endothelium. Blood 95(1):263-9. PubMed: 10607711MGI: J:110254
- Bulua AC; Simon A; Maddipati R; Pelletier M; Park H; Kim KY; Sack MN; Kastner DL; Siegel RM. 2011. Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J Exp Med 208(3):519-33. PubMed: 21282379MGI: J:176847
- Bunt SK; Yang L; Sinha P; Clements VK; Leips J; Ostrand-Rosenberg S. 2007. Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression. Cancer Res 67(20):10019-26. PubMed: 17942936MGI: J:126013
- Caffrey AK; Lehmann MM; Zickovich JM; Espinosa V; Shepardson KM; Watschke CP; Hilmer KM; Thammahong A; Barker BM; Rivera A; Cramer RA; Obar JJ. 2015. IL-1alpha signaling is critical for leukocyte recruitment after pulmonary Aspergillus fumigatus challenge. PLoS Pathog 11(1):e1004625. PubMed: 25629406MGI: J:248552
- Cai S; Batra S; Wakamatsu N; Pacher P; Jeyaseelan S. 2012. NLRC4 inflammasome-mediated production of IL-1beta modulates mucosal immunity in the lung against gram-negative bacterial infection. J Immunol 188(11):5623-35. PubMed: 22547706MGI: J:188721
- Carmi Y; Dotan S; Rider P; Kaplanov I; White MR; Baron R; Abutbul S; Huszar M; Dinarello CA; Apte RN; Voronov E. 2013. The Role of IL-1beta in the Early Tumor Cell-Induced Angiogenic Response. J Immunol 190(7):3500-9. PubMed: 23475218MGI: J:194907
- Cassel SL; Janczy JR; Bing X; Wilson SP; Olivier AK; Otero JE; Iwakura Y; Shayakhmetov DM; Bassuk AG; Abu-Amer Y; Brogden KA; Burns TL; Sutterwala FS; Ferguson PJ. 2014. Inflammasome-independent IL-1beta mediates autoinflammatory disease in Pstpip2-deficient mice. Proc Natl Acad Sci U S A 111(3):1072-7. PubMed: 24395802MGI: J:206468
- Ceballos-Olvera I; Sahoo M; Miller MA; Del Barrio L; Re F. 2011. Inflammasome-dependent pyroptosis and IL-18 protect against Burkholderia pseudomallei lung infection while IL-1beta is deleterious. PLoS Pathog 7(12):e1002452. PubMed: 22241982MGI: J:183297
- Chamberlain J; Evans D; King A; Dewberry R; Dower S; Crossman D; Francis S. 2006. Interleukin-1beta and signaling of interleukin-1 in vascular wall and circulating cells modulates the extent of neointima formation in mice. Am J Pathol 168(4):1396-403. PubMed: 16565512MGI: J:107324
- Chamberlain J; Francis S; Brookes Z; Shaw G; Graham D; Alp NJ; Dower S; Crossman DC. 2009. Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding. PLoS One 4(4):e5073. PubMed: 19347044MGI: J:148173
- Chamberlain J; Wheatcroft M; Arnold N; Lupton H; Crossman DC; Gunn J; Francis S. 2010. A novel mouse model of in situ stenting. Cardiovasc Res 85(1):38-44. PubMed: 19633315MGI: J:172559
- Chen CJ; Kono H; Golenbock D; Reed G; Akira S; Rock KL. 2007. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med 13(7):851-6. PubMed: 17572686MGI: J:125088
- Chen CJ; Shi Y; Hearn A; Fitzgerald K; Golenbock D; Reed G; Akira S; Rock KL. 2006. MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J Clin Invest 116(8):2262-71. PubMed: 16886064MGI: J:113110
- Chen CP; Hertzberg M; Jiang Y; Graves DT. 1999. Interleukin-1 and tumor necrosis factor receptor signaling is not required for bacteria-induced osteoclastogenesis and bone loss but is essential for protecting the host from a mixed anaerobic infection. Am J Pathol 155(6):2145-52. PubMed: 10595943MGI: J:58851
- Chen Q; Sen G; Snapper CM. 2006. Endogenous IL-1R1 signaling is critical for cognate CD4+ T cell help for induction of in vivo type 1 and type 2 antipolysaccharide and antiprotein Ig isotype responses to intact Streptococcus pneumoniae, but not to a soluble pneumococcal conjugate vaccine. J Immunol 177(9):6044-51. PubMed: 17056530MGI: J:140525
- Chen VL; Surana NK; Duan J; Kasper DL. 2013. Role of murine intestinal interleukin-1 receptor 1-expressing lymphoid tissue inducer-like cells in salmonella infection. PLoS One 8(6):e65405. PubMed: 23750260MGI: J:204259
- Chen YT; Chen FY; Vijmasi T; Stephens DN; Gallup M; McNamara NA. 2013. Pax6 downregulation mediates abnormal lineage commitment of the ocular surface epithelium in aqueous-deficient dry eye disease. PLoS One 8(10):e77286. PubMed: 24143217MGI: J:209118
- Chen YT; Lazarev S; Bahrami AF; Noble LB; Chen FY; Zhou D; Gallup M; Yadav M; McNamara NA. 2012. Interleukin-1 receptor mediates the interplay between CD4(+) T cells and ocular resident cells to promote keratinizing squamous metaplasia in Sjogren's syndrome. Lab Invest 92(4):556-70. PubMed: 22231738MGI: J:181948
- Chen YT; Nikulina K; Lazarev S; Bahrami AF; Noble LB; Gallup M; McNamara NA. 2010. Interleukin-1 as a phenotypic immunomodulator in keratinizing squamous metaplasia of the ocular surface in Sjogren's syndrome. Am J Pathol 177(3):1333-43. PubMed: 20696775MGI: J:163691
- Cho JS; Guo Y; Ramos RI; Hebroni F; Plaisier SB; Xuan C; Granick JL; Matsushima H; Takashima A; Iwakura Y; Cheung AL; Cheng G; Lee DJ; Simon SI; Miller LS. 2012. Neutrophil-derived IL-1beta is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. PLoS Pathog 8(11):e1003047. PubMed: 23209417MGI: J:195003
- Cho JS; Pietras EM; Garcia NC; Ramos RI; Farzam DM; Monroe HR; Magorien JE; Blauvelt A; Kolls JK; Cheung AL; Cheng G; Modlin RL; Miller LS. 2010. IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest 120(5):1762-73. PubMed: 20364087MGI: J:161481
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