These Nr5a1 knock-out mice exhibit adrenal and gonadal agenesis. They are suitable for use in applications related to the studies of adrenal and gonadal development and sexual differentiation.
Dr. Keith L. Parker, Univ Texas Southwestern Medical Center
Mice homozygous for the Nr5a1tm1Klp (formerly Ftzf1tm1Klp) targeted mutation exhibit adrenal and gonadal agenesis. There is also an absence of the ventromedial hypothalamic nucleus leading to impaired expression of gonadotrope specific markers.
|Allele Name||targeted mutation 1, Keith L Parker|
|Allele Type||Targeted (Null/Knockout)|
|Allele Synonym(s)||Ftz-F1; Ftz-F1-; Ftzf1tm1Klp; Sf-; SF-1; sf-1-; Sf1-|
|Gene Symbol and Name||Nr5a1, nuclear receptor subfamily 5, group A, member 1|
|Strain of Origin||129P2/OlaHsd|
|Molecular Note||A neomycin cassette was inserted into exon 4, which disrupted sequences encoding the second zinc finger of the DNA binding domain.|
|Mutations Made By|| |
Dr. Keith Parker, Univ Texas Southwestern Medical Center
This strain is maintained by mating heterozygous breeder pairs.
When using the Ftz-F1 KO mouse strain in a publication, please cite the originating article(s) and include JAX stock #003219 in your Materials and Methods section.