These WAPTag 3 mice express a transgene containing the SV40 large T antigen gene driven by the mouse whey acidic protein promoter.
Read More +Genetic Background | Generation |
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Allele Type |
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Transgenic (Inserted expressed sequence) |
Multiparous females of the WapTag3 lineage have hyperplastic mammary glands and occasionally develop mammary adenocarcinomas by 6 months of age. At this age, both males and females of this lineage develop osteosarcomas arising from the ospetrosium and renal adenocarcinomas. WAPTag3 females do not suckle their pups.
Expressed Gene | TAg, SV40 large T-antigen, SV40 |
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Site of Expression |
Allele Name | transgene insertion 3, Barbara B Knowles |
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Allele Type | Transgenic (Inserted expressed sequence) |
Allele Synonym(s) | WAPTAg3 |
Gene Symbol and Name | Tg(WapTAg)3Knw, transgene insertion 3, Barbara B Knowles |
Gene Synonym(s) | |
Promoter | Wap, whey acidic protein, mouse, laboratory |
Expressed Gene | TAg, SV40 large T-antigen, SV40 |
Strain of Origin | C57BL/6J |
Chromosome | UN |
Molecular Note | This transgene contains the mouse whey acidic protein promoter and the wild-type allele of the SV40 large T antigen gene. |
When maintaining a live colony, C57BL/6J inbred females (Stock No. 000664) may be bred to heterozygous males. WAPTag3 females do not suckle their pups.
When using the WAPTag 3 mouse strain in a publication, please cite the originating article(s) and include JAX stock #003189 in your Materials and Methods section.
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Carrier or non-carrier for Tg(WAPTAg)3Knw |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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