C57BL/6J-Tg(WAPTAg)3Knw/J

Stock number: 003189
Product name: WAPTag 3
Research areas: Cancer Research

Description

These WAPTag 3 mice express a transgene containing the SV40 large T antigen gene driven by the mouse whey acidic protein promoter.

Detailed description

Multiparous females of the WapTag3 lineage have hyperplastic mammary glands and occasionally develop mammary adenocarcinomas by 6 months of age. At this age, both males and females of this lineage develop osteosarcomas arising from the ospetrosium and renal adenocarcinomas. WAPTag3 females do not suckle their pups.

Allele

Symbol: Tg(WapTAg)3Knw
Name: transgene insertion 3, Barbara B Knowles
MGI accession ID: MGI:3040884
Generation method: Transgenic
Attributes: Inserted expressed sequence
Synonyms: WAPTAg3
Marker symbol: Tg(WapTAg)3Knw
Marker name: transgene insertion 3, Barbara B Knowles
Marker synonyms: WAPTAg3
Chromosome: UN
Strain of origin: C57BL/6J
Expressed genes: TAg,SV40 large T-antigen,SV40
Molecular note: This transgene contains the mouse whey acidic protein promoter and the wild-type allele of the SV40 large T antigen gene.