JAX
Mouse Strain Datasheet - 003175
C57BL/6-Il5tm1Kopf/J
Also Known As: IL-5-
These Il5 knock-out mice exhibit lack of eosinophilia response to infection and impaired CD5+ B-1 cell development.
Donating Investigator
Dr. Manfred Kopf, ETH Zurich
Genetic overview
| Genetic Background | Generation |
|---|---|
|
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Il5tm1Kopf
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Il5 | interleukin 5 |
Research Applications
- Cancer Research
- Immunology, Inflammation and Autoimmunity Research
Detailed Description
Mice homozygous for the Il5tm1Kopf targeted mutation are viable and fertile. Surprisingly, IL5 deficient mice show no defects in conventional B (B-2) cells, T cell dependent antibody production, or cytotoxic T cell responses. Eosinophilia response to infection is lacking in homozygous mutant mice. They also exhibit impaired CD5+ B-1 cell development.
Development
A targeting vector containing the neomycin resistance gene was used to disrupt exon 3. The construct was electroporated into C57BL/6J-derived BL/6-II embryonic stem (ES) cells. Correctly targeted ES cells were injected into blastocysts. The resulting chimeric animals were crossed to C57BL/6J.
Control Suggestions
Selected References
- Kopf M; Brombacher F; Hodgkin PD; Ramsay AJ; Milbourne EA; Dai WJ; Ovington KS; Behm CA; Kohler G; Young IG; Matthaei KI. 1996. IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity 4(1):15-24. PubMed: 8574848MGI: J:30867
Il5tm1Kopf
Allele Symbol: Il5tm1Kopf
| Allele Name | targeted mutation 1, Manfred A Kopf |
|---|---|
| Allele Type | Targeted (Null/Knockout) |
| Allele Synonym(s) | IL-5-; IL-5null |
| Gene Symbol and Name | Il5, interleukin 5 |
| Gene Synonym(s) | EDF; IL-5; Il-5; Il-5; TRF |
| Strain of Origin | C57BL/6J |
| Chromosome | 11 |
| Molecular Note | A neomycin resistance cassette was inserted into exon 3 of the gene. |
| Mutations Made By | Dr. Manfred Kopf, ETH Zurich |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
Genotype: Il5tm1Kopf related
- Cancer Research
- Growth Factors/Receptors/Cytokines
- Immunology, Inflammation and Autoimmunity Research
- Growth Factors/Receptors/Cytokines
Mammalian Phenotype Terms by Genotype
Genotype: Il5tm1Kopf/Il5tm1Kopf
C57BL/6-Il5tm1Kopf
respiratory system phenotype
- decreased airway responsiveness
- airways of aeroallergen-challenged knockout mice lose hyperresponsiveness to methacholine (MGI Ref ID J:30641)
immune system phenotype
- granulomatous inflammation
- pulmonary granulomas that form in knockout mice in response to schistosome eggs are almost completely devoid of eosinophils compared to granulomas in wild-type mice; the average size of granulomas in knockout mice are 40% smaller than those of wild-type (MGI Ref ID J:107418)
- there is a 20-25% increase in numbers of macrophages associated with granulomas in knockouts compared with wild-type; with acute or chronic parasite infection, the numbers of both fibroblasts and macrophages nearly double in knockout animals compared to wild typeild type (MGI Ref ID J:107418)
- increased interferon-gamma secretion
- in mesenteric lymph nodes in culture, there is a marked increase in IFNG production in knockouts compared to wild-type after restimulation with mitogen or SEA (MGI Ref ID J:107418)
- increased lymphocyte cell number
- after aerosolized OVA challenge, knockout mice have increased levels of lymphocytes in BALF compared to unchallenged animals but the increase is less pronounced than in wild-type mice (MGI Ref ID J:30641)
- increased neutrophil cell number
- after aerosolized OVA challenge, knockout mice have increased levels of neutrophils in BALF compared to unchallenged animals (MGI Ref ID J:30641)
liver/biliary system phenotype
- liver fibrosis
- hepatic fibrosis is significantly reduced in knockouts with acute or chronic helminth parasite infection (MGI Ref ID J:107418)
hematopoietic system phenotype
- increased lymphocyte cell number
- after aerosolized OVA challenge, knockout mice have increased levels of lymphocytes in BALF compared to unchallenged animals but the increase is less pronounced than in wild-type mice (MGI Ref ID J:30641)
- increased neutrophil cell number
- after aerosolized OVA challenge, knockout mice have increased levels of neutrophils in BALF compared to unchallenged animals (MGI Ref ID J:30641)
Genotype: Il5tm1Kopf/Il5tm1Kopf
C57BL/6-Il5tm1Kopf/J
immune system phenotype
- increased eosinophil cell number
- knockout mice infected with parasites do not show eosinophil counts above baseline values, while 35-week old controls develop eosinophilia in the blood, bone marrow and peritoneal cavity (MGI Ref ID J:30867)
hematopoietic system phenotype
- increased eosinophil cell number
- knockout mice infected with parasites do not show eosinophil counts above baseline values, while 35-week old controls develop eosinophilia in the blood, bone marrow and peritoneal cavity (MGI Ref ID J:30867)
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Il5tm1Kopf/Il5tm1Kopf
either: C57BL/6-Il5tm1Kopf or (involves: BALB/c * C57BL/6) or (involves: C57BL/6 * CBA)
embryo phenotype
- enlarged placenta
- knockout females have a significant increase in placenta size in matings with CBA males and the fetal:placental ratio is reduced (MGI Ref ID J:65853)
reproductive system phenotype
- prolonged estrous cycle
- duration of oestrus in knockouts is moderately extended (5.6 days versus 5 days in controls) (MGI Ref ID J:65853)
behavior/neurological phenotype
- abnormal mating receptivity
- Background Sensitivity - duration of mating interval to achieve mating with syngeneic (B6) versus allogeneic (CBA or BALB/c) males is increased (MGI Ref ID J:65853)
- after correction for male background, knockout females have significantly lower mating intervals than control females (MGI Ref ID J:65853)
growth/size/body region phenotype
- increased body weight
- Background Sensitivity - allogeneic matings produce larger pups than syngeneic pups; in CBA F1 pups, at weaning, female and male weights are increased 9.5 and 10%, while in C57BL/6 F1 pups, female and male weights at 6 weeks are increased by 7.9 and 12.2% (MGI Ref ID J:65853)
- Il5 deficient pups have an increased weight gain trajectory compared to wild-type; (MGI Ref ID J:65853)
- knockout pups are significantly larger than wild-type pups from birth to adulthood (MGI Ref ID J:65853)
References
- Kopf M; Brombacher F; Hodgkin PD; Ramsay AJ; Milbourne EA; Dai WJ; Ovington KS; Behm CA; Kohler G; Young IG; Matthaei KI. 1996. IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity 4(1):15-24. PubMed: 8574848MGI: J:30867
Additional References
- Coyle AJ; Kohler G; Tsuyuki S; Brombacher F; Kopf M. 1998. Eosinophils are not required to induce airway hyperresponsiveness after nematode infection. Eur J Immunol 28(9):2640-7. PubMed: 9754552MGI: J:50280
- Mishra A; Hogan SP; Brandt EB; Rothenberg ME. 2001. An etiological role for aeroallergens and eosinophils in experimental esophagitis. J Clin Invest 107(1):83-90. PubMed: 11134183MGI: J:66723
- Noffz G; Qin Z; Kopf M; Blankenstein T. 1998. Neutrophils but not eosinophils are involved in growth suppression of IL-4-secreting tumors. J Immunol 160(1):345-50. PubMed: 9551990MGI: J:46311
Additional - Il5tm1Kopf related
- Ankathatti Munegowda M; Xu S; Freywald A; Xiang J. 2012. CD4+ Th2 cells function alike effector Tr1 and Th1 cells through the deletion of a single cytokine IL-6 and IL-10 gene. Mol Immunol 51(2):143-9. PubMed: 22424785MGI: J:184874
- Apostolopoulos V; McKenzie IF; Lees C; Matthaei KI; Young IG. 2000. A role for IL-5 in the induction of cytotoxic T lymphocytes in vivo Eur J Immunol 30(6):1733-9. PubMed: 10898511MGI: J:62734
- Arras M; Louahed J; Heilier JF; Delos M; Brombacher F; Renauld JC; Lison D; Huaux F. 2005. IL-9 protects against bleomycin-induced lung injury: involvement of prostaglandins. Am J Pathol 166(1):107-15. PubMed: 15632004MGI: J:95244
- Babayan SA; Read AF; Lawrence RA; Bain O; Allen JE. 2010. Filarial parasites develop faster and reproduce earlier in response to host immune effectors that determine filarial life expectancy. PLoS Biol 8(10):e1000525. PubMed: 20976099MGI: J:167364
- Bao S; Beagley KW; Murray AM; Caristo V; Matthaei KI; Young IG; Husband AJ. 1998. Intestinal IgA plasma cells of the B1 lineage are IL-5 dependent. Immunology 94(2):181-8. PubMed: 9741339MGI: J:112427
- Binder CJ; Hartvigsen K; Chang MK; Miller M; Broide D; Palinski W; Curtiss LK; Corr M; Witztum JL. 2004. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest 114(3):427-37. PubMed: 15286809MGI: J:118092
- Brunet LR; Sabin EA; Cheever AW; Kopf MA; Pearce EJ. 1999. Interleukin 5 (IL-5) is not required for expression of a Th2 response or host resistance mechanisms during murine schistosomiasis mansoni but does play a role in development of IL-4-producing non-T, non-B cells. Infect Immun 67(6):3014-8. PubMed: 10338513MGI: J:55454
- Cenci E; Mencacci A; Del Sero G; Bacci A; Montagnoli C; d'Ostiani CF; Mosci P; Bachmann M; Bistoni F; Kopf M; Romani L. 1999. Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses. J Infect Dis 180(6):1957-68. PubMed: 10558953MGI: J:119841
- Cho JY; Miller M; Baek KJ; Han JW; Nayar J; Lee SY; McElwain K; McElwain S; Friedman S; Broide DH. 2004. Inhibition of airway remodeling in IL-5-deficient mice. J Clin Invest 113(4):551-60. PubMed: 14966564MGI: J:88171
- Cohn L; Homer RJ; MacLeod H; Mohrs M; Brombacher F; Bottomly K. 1999. Th2-induced airway mucus production is dependent on IL-4Ralpha, but not on eosinophils. J Immunol 162(10):6178-83. PubMed: 10229862MGI: J:119786
- Denkinger CM; Denkinger MD; Forsthuber TG. 2007. Pertussis toxin-induced cytokine differentiation and clonal expansion of T cells is mediated predominantly via costimulation. Cell Immunol 246(1):46-54. PubMed: 17601518MGI: J:123551
- Diny NL; Baldeviano GC; Talor MV; Barin JG; Ong S; Bedja D; Hays AG; Gilotra NA; Coppens I; Rose NR; Cihakova D. 2017. Eosinophil-derived IL-4 drives progression of myocarditis to inflammatory dilated cardiomyopathy. J Exp Med 214(4):943-957. PubMed: 28302646MGI: J:241865
- Dixon H; Blanchard C; Deschoolmeester ML; Yuill NC; Christie JW; Rothenberg ME; Else KJ. 2006. The role of Th2 cytokines, chemokines and parasite products in eosinophil recruitment to the gastrointestinal mucosa during helminth infection. Eur J Immunol 36(7):1753-63. PubMed: 16783848MGI: J:115793
- Domachowske JB; Bonville CA; Easton AJ; Rosenberg HF. 2002. Pulmonary eosinophilia in mice devoid of interleukin-5. J Leukoc Biol 71(6):966-72. PubMed: 12050181MGI: J:124313
- Forbes E; Murase T; Yang M; Matthaei KI; Lee JJ; Lee NA; Foster PS; Hogan SP. 2004. Immunopathogenesis of experimental ulcerative colitis is mediated by eosinophil peroxidase. J Immunol 172(9):5664-75. PubMed: 15100311MGI: J:89683
- Foster PS; Hogan SP; Ramsay AJ; Matthaei KI; Young IG. 1996. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model [see comments] J Exp Med 183(1):195-201. PubMed: 8551223MGI: J:30641
- Hamelmann E; Takeda K; Haczku A; Cieslewicz G; Shultz L; Hamid Q; Xing Z; Gauldie J; Gelfand EW. 2000. Interleukin (IL)-5 but not immunoglobulin E reconstitutes airway inflammation and airway hyperresponsiveness in IL-4-deficient mice. Am J Respir Cell Mol Biol 23(3):327-34. PubMed: 10970823MGI: J:114176
- Hao H; Cohen DA; Jennings CD; Bryson JS; Kaplan AM. 2000. Bleomycin-induced pulmonary fibrosis is independent of eosinophils J Leukoc Biol 68(4):515-21. PubMed: 11037973MGI: J:65583
- Herbert DR; Lee JJ; Lee NA; Nolan TJ; Schad GA; Abraham D. 2000. Role of IL-5 in innate and adaptive immunity to larval Strongyloides stercoralis in mice. J Immunol 165(8):4544-51. PubMed: 11035095MGI: J:119216
- Hofstetter HH; Sewell DL; Liu F; Sandor M; Forsthuber T; Lehmann PV; Fabry Z. 2003. Autoreactive T cells promote post-traumatic healing in the central nervous system. J Neuroimmunol 134(1-2):25-34. PubMed: 12507769MGI: J:119263
- Hogan SP; Matthaei KI; Young JM; Koskinen A; Young IG; Foster PS. 1998. A novel T cell-regulated mechanism modulating allergen-induced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5. J Immunol 161(3):1501-9. PubMed: 9686617MGI: J:48882
- Hogan SP; Mishra A; Brandt EB; Foster PS; Rothenberg ME. 2000. A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy. Proc Natl Acad Sci U S A 97(12):6681-6. PubMed: 10841566MGI: J:62718
- Huaux F; Liu T; McGarry B; Ullenbruch M; Xing Z; Phan SH. 2003. Eosinophils and T lymphocytes possess distinct roles in bleomycin-induced lung injury and fibrosis. J Immunol 171(10):5470-81. PubMed: 14607953MGI: J:119211
- Hung K; Hayashi R; Lafond-Walker A; Lowenstein C; Pardoll D; Levitsky H. 1998. The central role of CD4(+) T cells in the antitumor immune response. J Exp Med 188(12):2357-68. PubMed: 9858522MGI: J:51677
- Jacobsen EA; Zellner KR; Colbert D; Lee NA; Lee JJ. 2011. Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation. J Immunol 187(11):6059-68. PubMed: 22048766MGI: J:179701
- MacDonald AS; Loke P; Allen JE. 1999. Suppressive antigen-presenting cells in Helminth infection. Pathobiology 67(5-6):265-8. PubMed: 10725799MGI: J:61096
- Mattes J; Yang M; Mahalingam S; Kuehr J; Webb DC; Simson L; Hogan SP; Koskinen A; McKenzie AN; Dent LA; Rothenberg ME; Matthaei KI; Young IG; Foster PS. 2002. Intrinsic defect in T cell production of interleukin (IL)-13 in the absence of both IL-5 and eotaxin precludes the development of eosinophilia and airways hyperreactivity in experimental asthma. J Exp Med 195(11):1433-44. PubMed: 12045241MGI: J:116794
- McKee AS; Munks MW; MacLeod MK; Fleenor CJ; Van Rooijen N; Kappler JW; Marrack P. 2009. Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. J Immunol 183(7):4403-14. PubMed: 19734227MGI: J:152787
- Mishra A; Hogan SP; Brandt EB; Rothenberg ME. 2002. IL-5 promotes eosinophil trafficking to the esophagus. J Immunol 168(5):2464-9. PubMed: 11859139MGI: J:74724
- Mishra A; Wang M; Pemmaraju VR; Collins MH; Fulkerson PC; Abonia JP; Blanchard C; Putnam PE; Rothenberg ME. 2008. Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia. Gastroenterology 134(1):204-14. PubMed: 18166354MGI: J:135588
- Moon BG; Takaki S; Miyake K; Takatsu K. 2004. The role of IL-5 for mature B-1 cells in homeostatic proliferation, cell survival, and Ig production. J Immunol 172(10):6020-9. PubMed: 15128785MGI: J:89849
- Munks MW; McKee AS; Macleod MK; Powell RL; Degen JL; Reisdorph NA; Kappler JW; Marrack P. 2010. Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo. Blood 116(24):5191-9. PubMed: 20876456MGI: J:167390
- Noffz G; Qin Z; Kopf M; Blankenstein T. 1998. Neutrophils but not eosinophils are involved in growth suppression of IL-4-secreting tumors. J Immunol 160(1):345-50. PubMed: 9551990MGI: J:46311
- Ovington KS; McKie K; Matthaei KI; Young IG; Behm CA. 1998. Regulation of primary Strongyloides ratti infections in mice: a role for interleukin-5. Immunology 95(3):488-93. PubMed: 9824515MGI: J:51185
- Padilla J; Daley E; Chow A; Robinson K; Parthasarathi K; McKenzie AN; Tschernig T; Kurup VP; Donaldson DD; Grunig G. 2005. IL-13 regulates the immune response to inhaled antigens. J Immunol 174(12):8097-105. PubMed: 15944318MGI: J:100867
- Peebles RS Jr; Hashimoto K; Sheller JR; Moore ML; Morrow JD; Ji S; Elias JA; Goleniewska K; O'neal J; Mitchell DB; Graham BS; Zhou W. 2005. Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependent. J Immunol 175(12):8253-9. PubMed: 16339565MGI: J:122257
- Pochanke V; Hatak S; Hengartner H; Zinkernagel RM; McCoy KD. 2006. Induction of IgE and allergic-type responses in fur mite-infested mice. Eur J Immunol 36(9):2434-45. PubMed: 16909433MGI: J:116736
- Pope SM; Brandt EB; Mishra A; Hogan SP; Zimmermann N; Matthaei KI; Foster PS; Rothenberg ME. 2001. IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism. J Allergy Clin Immunol 108(4):594-601. PubMed: 11590387MGI: J:96752
- Ramalingam T; Ganley-Leal L; Porte P; Rajan TV. 2003. Impaired clearance of primary but not secondary Brugia infections in IL-5 deficient mice. Exp Parasitol 105(2):131-9. PubMed: 14969690MGI: J:102607
- Reiman RM; Thompson RW; Feng CG; Hari D; Knight R; Cheever AW; Rosenberg HF; Wynn TA. 2006. Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activity. Infect Immun 74(3):1471-9. PubMed: 16495517MGI: J:107418
- Roa J; Morikawa H; Crawford L; Baatjes A; Duong M; Denburg JA. 2007. The effects of montelukast on tissue inflammatory and bone marrow responses in murine experimental allergic rhinitis: interaction with interleukin-5 deficiency. Immunology 122(3):438-44. PubMed: 17627772MGI: J:127184
- Robertson SA; Mau VJ; Young IG; Matthaei KI. 2000. Uterine eosinophils and reproductive performance in interleukin 5-deficient mice. J Reprod Fertil 120(2):423-32. PubMed: 11058459MGI: J:65853
- Saito H; Matsumoto K; Denburg AE; Crawford L; Ellis R; Inman MD; Sehmi R; Takatsu K; Matthaei KI; Denburg JA. 2002. Pathogenesis of murine experimental allergic rhinitis: a study of local and systemic consequences of IL-5 deficiency. J Immunol 168(6):3017-23. PubMed: 11884474MGI: J:126473
- Schwarze J; Cieslewicz G; Hamelmann E; Joetham A; Shultz LD; Lamers MC; Gelfand EW. 1999. IL-5 and eosinophils are essential for the development of airway hyperresponsiveness following acute respiratory syncytial virus infection. J Immunol 162(5):2997-3004. PubMed: 10072551MGI: J:110844
- Sharkhuu T; Matthaei KI; Forbes E; Mahalingam S; Hogan SP; Hansbro PM; Foster PS. 2006. Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivity. Clin Exp Allergy 36(12):1575-83. PubMed: 17177681MGI: J:135913
- Simons JE; Rothenberg ME; Lawrence RA. 2005. Eotaxin-1-regulated eosinophils have a critical role in innate immunity against experimental Brugia malayi infection. Eur J Immunol 35(1):189-97. PubMed: 15593125MGI: J:95225
- Spergel JM; Mizoguchi E; Oettgen H; Bhan AK; Geha RS. 1999. Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis. J Clin Invest 103(8):1103-11. PubMed: 10207161MGI: J:119611
- Swartz JM; Bystrom J; Dyer KD; Nitto T; Wynn TA; Rosenberg HF. 2004. Plasminogen activator inhibitor-2 (PAI-2) in eosinophilic leukocytes. J Leukoc Biol 76(4):812-9. PubMed: 15277569MGI: J:92977
- Temann UA; Laouar Y; Eynon EE; Homer R; Flavell RA. 2007. IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells. Int Immunol 19(1):1-10. PubMed: 17101709MGI: J:118163
- Vallance BA; Blennerhassett PA; Deng Y; Matthaei KI; Young IG; Collins SM. 1999. IL-5 contributes to worm expulsion and muscle hypercontractility in a primary T. spiralis infection. Am J Physiol 277(2 Pt 1):G400-8. PubMed: 10444455MGI: J:56839
- Vallance BA; Matthaei KI; Sanovic S; Young IG; Collins SM. 2000. Interleukin-5 deficient mice exhibit impaired host defence against challenge Trichinella spiralis infections. Parasite Immunol 22(10):487-92. PubMed: 11012974MGI: J:103984
- Vink A; Warnier G; Brombacher F; Renauld JC. 1999. Interleukin 9-induced in vivo expansion of the B-1 lymphocyte population. J Exp Med 189(9):1413-23. PubMed: 10224281MGI: J:136446
- Walsh MP; Duncan B; Larabee S; Krauss A; Davis JP; Cui Y; Kim SY; Guimond M; Bachovchin W; Fry TJ. 2013. Val-boroPro accelerates T cell priming via modulation of dendritic cell trafficking resulting in complete regression of established murine tumors. PLoS One 8(3):e58860. PubMed: 23554941MGI: J:200168
- Wang J; Palmer K; Lotvall J; Milan S; Lei XF; Matthaei KI; Gauldie J; Inman MD; Jordana M; Xing Z. 1998. Circulating, but not local lung, IL-5 is required for the development of antigen-induced airways eosinophilia. J Clin Invest 102(6):1132-41. PubMed: 9739047MGI: J:115210
- Webb DC; Mahalingam S; Cai Y; Matthaei KI; Donaldson DD; Foster PS. 2003. Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4Ralpha-independent airway hyperreactivity. Eur J Immunol 33(12):3377-85. PubMed: 14635046MGI: J:87139
- Weir C; Bernard CC; Backstrom BT. 2003. IL-5-deficient mice are susceptible to experimental autoimmune encephalomyelitis. Int Immunol 15(11):1283-9. PubMed: 14565926MGI: J:110934
- Wensky AK; Furtado GC; Marcondes MC; Chen S; Manfra D; Lira SA; Zagzag D; Lafaille JJ. 2005. IFN-gamma determines distinct clinical outcomes in autoimmune encephalomyelitis. J Immunol 174(3):1416-23. PubMed: 15661899MGI: J:110017
- Wu CA; Peluso JJ; Zhu L; Lingenheld EG; Walker ST; Puddington L. 2010. Bronchial epithelial cells produce IL-5: implications for local immune responses in the airways. Cell Immunol 264(1):32-41. PubMed: 20494340MGI: J:162110
- Yang M; Hogan SP; Henry PJ; Matthaei KI; McKenzie AN; Young IG; Rothenberg ME; Foster PS. 2001. Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin. Am J Respir Cell Mol Biol 25(4):522-30. PubMed: 11694459MGI: J:114421
- Zarei S; Schwenter F; Luy P; Aurrand-Lions M; Morel P; Kopf M; Dranoff G; Mach N. 2009. Role of GM-CSF signaling in cell-based tumor immunization. Blood 113(26):6658-68. PubMed: 19282460MGI: J:150155
- Zhang Y; Denkers EY. 1999. Protective role for interleukin-5 during chronic Toxoplasma gondii infection. Infect Immun 67(9):4383-92. PubMed: 10456878MGI: J:57116