The phenotype of this transgene on a B10.D2nSnJ genetic background (Stock No. <a href="https://www.jax.org/strain/003183"">003183</a>) is as follows: <p>
Hemizygous mice carry the immunoglobulin transgene Tg(Igh2k3-83)1Nemz. Results indicate that B cells specific for major histocompatibility complex class I antigen can be deleted if they encounter membrane-bound antigen at a post-bone-marrow stage of development. This deletion may be necessary to prevent organ-specific autoimmunity. The 3-83 transgenic only produce B-lymphocytes that make a single type of antibody with a defined specificity whose presence or absence can be easily monitored with several different reagents. Thus, they are invaluable to investigators who wish to determine how the development of a specific antibody specificity is genetically controlled. This is an important question in determining both how immune responses are generated against infectious agents, while normally preventing the development of antibodies against self-proteins which can lead to serious autoimmune diseases such as lupus. The 3-83 mice can also be used to dissect the antibody production role of B-lymphocytes from their antigen presenting cell functions.


These Tol 1 mice express a transgene, on the NOD/Lt genetic background, containing a gene for IgM anti-H-2<sup>k</sup> MHC class I antibody.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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