JAX
Mouse Strain Datasheet - 003170
FVB.Cg-Tg(Myh6-tTA)6Smbf/J
Also Known As: 2.9alphatTA
This strain may be useful for generating conditional expression of target genes in cardiac myocytes.
Donating Investigator
Dr. Glenn I. Fishman, NYU School of Medicine
Genetic overview
| Genetic Background | Generation |
|---|---|
|
?pN1+N1F10
(19-SEP-16) |
Tg(Myh6-tTA)6Smbf
| Allele Type |
|---|
| Transgenic (Transactivator) |
Base Price
Starting at:
| $263.00 Domestic price for female |
| $337.00 Domestic price for breeder pair |
Important Note
This strain is homozygous for the retinal degeneration allele Pde6brd1.
Detailed Description
This strain expresses the tetracycline-controlled transactivator protein (tTA) under the regulatory control of the rat alpha myosin heavy chain promoter, which directs expression of tTA, specifically, in cardiac myocytes. When these Myh6-tTA (also called 2.9alphatTA or MHCAtTA) transgenic mice are mated to a second transgenic strain carrying a gene of interest coupled to a tetracycline-responsive promoter element (TRE), conditional expression of the target gene in cardiac myocytes may be controlled by the administration of tetracycline or doxycycline.
Development
A transgene in which ~ 2.9kb of 5' flanking sequence from the rat alpha myosin heavy chain gene drives expression of the tetracycline-controlled transactivator (tTA) was microinjected into C57BL/6xCBA F1 hybrid pronuclei. Subsequently, the strain was backcrossed to FVB/N for at least 8 generations.
Expression Data
| Expressed Gene | tTA, tetracycline-controlled transactivator, E. coli |
|---|---|
| Site of Expression | Expresses tTA in cardiac myocytes. |
Control Suggestions
Selected References
- Yu Z; Redfern CS; Fishman GI. 1996. Conditional transgene expression in the heart. Circ Res 79(4):691-7. PubMed: 8831492MGI: J:82692
Tg(Myh6-tTA)6Smbf
Allele Symbol: Tg(Myh6-tTA)6Smbf
| Allele Name | transgene insertion 6, Section of Myocardial Biology - Fishman Lab |
|---|---|
| Allele Type | Transgenic (Transactivator) |
| Allele Synonym(s) | 2.9alphatTA; Tg(MHCAtTA)6Smbf; alphaMHC-tTA; alphaMtTA |
| Gene Symbol and Name | Tg(Myh6-tTA)6Smbf, transgene insertion 6, Section of Myocardial Biology - Fishman Lab |
| Gene Synonym(s) | 2.9alphatTA; Tg(MHCAtTA)6Smbf; alphaMHC-tTA |
| Promoter | Myh6, myosin heavy chain 6, rat |
| Expressed Gene | tTA, tetracycline-controlled transactivator, E. coli |
| Site of Expression | Expresses tTA in cardiac myocytes. |
| Strain of Origin | (C57BL/6 x CBA)F1 |
| Chromosome | UN |
| General Note | Transgenic line 6 showed the strongest cardiac transgene expression and was used for analysis. |
| Molecular Note | The transgene consists of a rat Myh6 promoter and a tetracycline transactivator sequence. Transgene expression in cardiac tissue was confirmed by Northern blot analysis. 2.9 kb of rat Myh6 promoter sequences directs transgene expression in the heart starting at embryonic day E7.5. |
| Mutations Made By | Dr. Glenn Fishman, NYU School of Medicine |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Cardiovascular Research
- Tet Expression Systems
- tTA/rtTA Expressing Strains
References
- Yu Z; Redfern CS; Fishman GI. 1996. Conditional transgene expression in the heart. Circ Res 79(4):691-7. PubMed: 8831492MGI: J:82692
Additional References
- Bowman JC; Steinberg SF; Jiang T; Geenen DL; Fishman GI; Buttrick PM. 1997. Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates. J Clin Invest 100(9):2189-95. PubMed: 9410895MGI: J:43986
- Ward NL; Van Slyke P; Sturk C; Cruz M; Dumont DJ. 2004. Angiopoietin 1 expression levels in the myocardium direct coronary vessel development. Dev Dyn 229(3):500-9. PubMed: 14991706MGI: J:88848
Additional - Tg(Myh6-tTA)6Smbf related
- Ainscough JF; Drinkhill MJ; Sedo A; Turner NA; Brooke DA; Balmforth AJ; Ball SG. 2009. Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction. Cardiovasc Res 81(3):592-600. PubMed: 18703536MGI: J:162208
- Akasaki Y; Ouchi N; Izumiya Y; Bernardo BL; Lebrasseur NK; Walsh K. 2014. Glycolytic fast-twitch muscle fiber restoration counters adverse age-related changes in body composition and metabolism. Aging Cell 13(1):80-91. PubMed: 24033924MGI: J:216107
- Bageghni SA; Frentzou GA; Drinkhill MJ; Mansfield W; Coverley D; Ainscough JF. 2017. Cardiomyocyte--specific expression of the nuclear matrix protein, CIZ1, stimulates production of mono-nucleated cells with an extended window of proliferation in the postnatal mouse heart. Biol Open 6(1):92-99. PubMed: 27934662MGI: J:238715
- Baker AJ; Redfern CH; Harwood MD; Simpson PC; Conklin BR. 2001. Abnormal contraction caused by expression of G(i)-coupled receptor in transgenic model of dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 280(4):H1653-9. PubMed: 11247776MGI: J:128598
- Barandon L; Dufourcq P; Costet P; Moreau C; Allieres C; Daret D; Dos Santos P; Daniel Lamaziere JM; Couffinhal T; Duplaa C. 2005. Involvement of FrzA/sFRP-1 and the Wnt/frizzled pathway in ischemic preconditioning. Circ Res 96(12):1299-306. PubMed: 15920021MGI: J:110294
- Berry JM; Le V; Rotter D; Battiprolu PK; Grinsfelder B; Tannous P; Burchfield JS; Czubryt M; Backs J; Olson EN; Rothermel BA; Hill JA. 2011. Reversibility of adverse, calcineurin-dependent cardiac remodeling. Circ Res 109(4):407-17. PubMed: 21700928MGI: J:186602
- Bowman JC; Steinberg SF; Jiang T; Geenen DL; Fishman GI; Buttrick PM. 1997. Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates. J Clin Invest 100(9):2189-95. PubMed: 9410895MGI: J:43986
- Burkard N; Rokita AG; Kaufmann SG; Hallhuber M; Wu R; Hu K; Hofmann U; Bonz A; Frantz S; Cartwright EJ; Neyses L; Maier LS; Maier SK; Renne T; Schuh K; Ritter O. 2007. Conditional neuronal nitric oxide synthase overexpression impairs myocardial contractility. Circ Res 100(3):e32-44. PubMed: 17272813MGI: J:133706
- Burkard N; Williams T; Czolbe M; Blomer N; Panther F; Link M; Fraccarollo D; Widder JD; Hu K; Han H; Hofmann U; Frantz S; Nordbeck P; Bulla J; Schuh K; Ritter O. 2010. Conditional overexpression of neuronal nitric oxide synthase is cardioprotective in ischemia/reperfusion. Circulation 122(16):1588-603. PubMed: 20921441MGI: J:179484
- Callis TE; Pandya K; Seok HY; Tang RH; Tatsuguchi M; Huang ZP; Chen JF; Deng Z; Gunn B; Shumate J; Willis MS; Selzman CH; Wang DZ. 2009. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest 119(9):2772-86. PubMed: 19726871MGI: J:152696
- Czubryt MP; McAnally J; Fishman GI; Olson EN. 2003. Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha ) and mitochondrial function by MEF2 and HDAC5. Proc Natl Acad Sci U S A 100(4):1711-6. PubMed: 12578979MGI: J:81967
- Dalal S; Zha Q; Daniels CR; Steagall RJ; Joyner WL; Gadeau AP; Singh M; Singh K. 2014. Osteopontin stimulates apoptosis in adult cardiac myocytes via the involvement of CD44 receptors, mitochondrial death pathway, and endoplasmic reticulum stress. Am J Physiol Heart Circ Physiol 306(8):H1182-91. PubMed: 24531809MGI: J:210479
- Dor Y; Camenisch TD; Itin A; Fishman GI; McDonald JA; Carmeliet P; Keshet E. 2001. A novel role for VEGF in endocardial cushion formation and its potential contribution to congenital heart defects. Development 128(9):1531-8. PubMed: 11290292MGI: J:68214
- Dor Y; Djonov V; Abramovitch R; Itin A; Fishman GI; Carmeliet P; Goelman G; Keshet E. 2002. Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy. EMBO J 21(8):1939-47. PubMed: 11953313MGI: J:76143
- Elsherif L; Wang X; Grachoff M; Wolska BM; Geenen DL; O'Bryan JP. 2012. Cardiac-specific expression of the tetracycline transactivator confers increased heart function and survival following ischemia reperfusion injury. PLoS One 7(1):e30129. PubMed: 22272284MGI: J:179877
- Favre J; Gao J; Di Zang A; Remy-Jouet I; Ouvrard-Pascaud A; Dautreaux B; Escoubet B; Thuillez C; Jaisser F; Richard V. 2011. Coronary endothelial dysfunction after cardiomyocyte-specific mineralocorticoid receptor overexpression. Am J Physiol Heart Circ Physiol :. PubMed: 21441311MGI: J:170305
- Gao MH; Bayat H; Roth DM; Yao Zhou J; Drumm J; Burhan J; Hammond HK. 2002. Controlled expression of cardiac-directed adenylylcyclase type VI provides increased contractile function. Cardiovasc Res 56(2):197-204. PubMed: 12393090MGI: J:132260
- Gellen B; Fernandez-Velasco M; Briec F; Vinet L; LeQuang K; Rouet-Benzineb P; Benitah JP; Pezet M; Palais G; Pellegrin N; Zhang A; Perrier R; Escoubet B; Marniquet X; Richard S; Jaisser F; Gomez AM; Charpentier F; Mercadier JJ. 2008. Conditional FKBP12.6 overexpression in mouse cardiac myocytes prevents triggered ventricular tachycardia through specific alterations in excitation-contraction coupling. Circulation 117(14):1778-86. PubMed: 18378612MGI: J:153299
- Gomez AM; Rueda A; Sainte-Marie Y; Pereira L; Zissimopoulos S; Zhu X; Schaub R; Perrier E; Perrier R; Latouche C; Richard S; Picot MC; Jaisser F; Lai FA; Valdivia HH; Benitah JP. 2009. Mineralocorticoid modulation of cardiac ryanodine receptor activity is associated with downregulation of FK506-binding proteins. Circulation 119(16):2179-87. PubMed: 19364981MGI: J:166494
- Grunewald M; Avraham I; Dor Y; Bachar-Lustig E; Itin A; Jung S; Chimenti S; Landsman L; Abramovitch R; Keshet E. 2006. VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell 124(1):175-89. PubMed: 16413490MGI: J:115908
- Guo A; Zhang X; Iyer VR; Chen B; Zhang C; Kutschke WJ; Weiss RM; Franzini-Armstrong C; Song LS. 2014. Overexpression of junctophilin-2 does not enhance baseline function but attenuates heart failure development after cardiac stress. Proc Natl Acad Sci U S A 111(33):12240-5. PubMed: 25092313MGI: J:213927
- Hirotani S; Zhai P; Tomita H; Galeotti J; Marquez JP; Gao S; Hong C; Yatani A; Avila J; Sadoshima J. 2007. Inhibition of glycogen synthase kinase 3beta during heart failure is protective. Circ Res 101(11):1164-74. PubMed: 17901358MGI: J:142787
- Huang L; Wolska BM; Montgomery DE; Burkart EM; Buttrick PM; Solaro RJ. 2001. Increased contractility and altered Ca(2+) transients of mouse heart myocytes conditionally expressing PKCbeta. Am J Physiol Cell Physiol 280(5):C1114-20. PubMed: 11287324MGI: J:128800
- Jaba IM; Zhuang ZW; Li N; Jiang Y; Martin KA; Sinusas AJ; Papademetris X; Simons M; Sessa WC; Young LH; Tirziu D. 2013. NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth. J Clin Invest 123(4):1718-31. PubMed: 23454748MGI: J:197567
- Latouche C; Sainte-Marie Y; Steenman M; Castro Chaves P; Naray-Fejes-Toth A; Fejes-Toth G; Farman N; Jaisser F. 2010. Molecular signature of mineralocorticoid receptor signaling in cardiomyocytes: from cultured cells to mouse heart. Endocrinology 151(9):4467-76. PubMed: 20591974MGI: J:165690
- Lee P; Morley G; Huang Q; Fischer A; Seiler S; Horner JW; Factor S; Vaidya D; Jalife J; Fishman GI. 1998. Conditional lineage ablation to model human diseases. Proc Natl Acad Sci U S A 95(19):11371-6. PubMed: 9736743MGI: J:128617
- Loyer X; Gomez AM; Milliez P; Fernandez-Velasco M; Vangheluwe P; Vinet L; Charue D; Vaudin E; Zhang W; Sainte-Marie Y; Robidel E; Marty I; Mayer B; Jaisser F; Mercadier JJ; Richard S; Shah AM; Benitah JP; Samuel JL; Heymes C. 2008. Cardiomyocyte overexpression of neuronal nitric oxide synthase delays transition toward heart failure in response to pressure overload by preserving calcium cycling. Circulation 117(25):3187-98. PubMed: 18541744MGI: J:155077
- Lu S; Crawford GL; Dore J; Anderson SA; Despres D; Horowits R. 2011. Cardiac-specific NRAP overexpression causes right ventricular dysfunction in mice. Exp Cell Res 317(8):1226-37. PubMed: 21276443MGI: J:170859
- Maier HJ; Schips TG; Wietelmann A; Kruger M; Brunner C; Sauter M; Klingel K; Bottger T; Braun T; Wirth T. 2012. Cardiomyocyte-specific IkappaB kinase (IKK)/NF-kappaB activation induces reversible inflammatory cardiomyopathy and heart failure. Proc Natl Acad Sci U S A 109(29):11794-9. PubMed: 22753500MGI: J:186490
- May D; Gilon D; Djonov V; Itin A; Lazarus A; Gordon O; Rosenberger C; Keshet E. 2008. Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation. Proc Natl Acad Sci U S A 105(1):282-7. PubMed: 18162550MGI: J:131069
- Mayr M; May D; Gordon O; Madhu B; Gilon D; Yin X; Xing Q; Drozdov I; Ainali C; Tsoka S; Xu Q; Griffiths J; Horrevoets A; Keshet E. 2011. Metabolic homeostasis is maintained in myocardial hibernation by adaptive changes in the transcriptome and proteome. J Mol Cell Cardiol 50(6):982-90. PubMed: 21354174MGI: J:172827
- McCloskey DT; Turcato S; Wang GY; Turnbull L; Zhu BQ; Bambino T; Nguyen AP; Lovett DH; Nissenson RA; Karliner JS; Baker AJ. 2008. Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 294(1):H205-12. PubMed: 17965283MGI: J:132451
- McCloskey DT; Turnbull L; Swigart PM; Zambon AC; Turcato S; Joho S; Grossman W; Conklin BR; Simpson PC; Baker AJ. 2005. Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression. Physiol Genomics 22(1):118-26. PubMed: 15797971MGI: J:99311
- Mesirca P; Alig J; Torrente AG; Muller JC; Marger L; Rollin A; Marquilly C; Vincent A; Dubel S; Bidaud I; Fernandez A; Seniuk A; Engeland B; Singh J; Miquerol L; Ehmke H; Eschenhagen T; Nargeot J; Wickman K; Isbrandt D; Mangoni ME. 2014. Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation. Nat Commun 5:4664. PubMed: 25144323MGI: J:225207
- Montano MM; Desjardins CL; Doughman YQ; Hsieh YH; Hu Y; Bensinger HM; Wang C; Stelzer JE; Dick TE; Hoit BD; Chandler MP; Yu X; Watanabe M. 2013. Inducible re-expression of HEXIM1 causes physiological cardiac hypertrophy in the adult mouse. Cardiovasc Res 99(1):74-82. PubMed: 23585471MGI: J:211395
- Mueller EE; Momen A; Masse S; Zhou YQ; Liu J; Backx PH; Henkelman RM; Nanthakumar K; Stewart DJ; Husain M. 2011. Electrical remodelling precedes heart failure in an endothelin-1-induced model of cardiomyopathy. Cardiovasc Res 89(3):623-33. PubMed: 21062919MGI: J:186883
- Mungrue IN; Gros R; You X; Pirani A; Azad A; Csont T; Schulz R; Butany J; Stewart DJ; Husain M. 2002. Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death. J Clin Invest 109(6):735-43. PubMed: 11901182MGI: J:132082
- Oshima Y; Ouchi N; Sato K; Izumiya Y; Pimentel DR; Walsh K. 2008. Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart. Circulation 117(24):3099-108. PubMed: 18519848MGI: J:155080
- Ouvrard-Pascaud A; Sainte-Marie Y; Benitah JP; Perrier R; Soukaseum C; Cat AN; Royer A; Le Quang K; Charpentier F; Demolombe S; Mechta-Grigoriou F; Beggah AT; Maison-Blanche P; Oblin ME; Delcayre C; Fishman GI; Farman N; Escoubet B; Jaisser F. 2005. Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias. Circulation 111(23):3025-33. PubMed: 15939817MGI: J:112171
- Palais G; Nguyen Dinh Cat A; Friedman H; Panek-Huet N; Millet A; Tronche F; Gellen B; Mercadier JJ; Peterson A; Jaisser F. 2009. Targeted transgenesis at the HPRT locus: an efficient strategy to achieve tightly controlled in vivo conditional expression with the tet system. Physiol Genomics 37(2):140-6. PubMed: 19141541MGI: J:157969
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- Redfern CH; Coward P; Degtyarev MY; Lee EK; Kwa AT; Hennighausen L; Bujard H; Fishman GI; Conklin BR. 1999. Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice. Nat Biotechnol 17(2):165-9. PubMed: 10052353MGI: J:95090
- Redfern CH; Degtyarev MY; Kwa AT; Salomonis N; Cotte N; Nanevicz T; Fidelman N; Desai K; Vranizan K; Lee EK; Coward P; Shah N; Warrington JA; Fishman GI; Bernstein D; Baker AJ; Conklin BR. 2000. Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy. Proc Natl Acad Sci U S A 97(9):4826-31. PubMed: 10781088MGI: J:107363
- Renault MA; Robbesyn F; Reant P; Douin V; Daret D; Allieres C; Belloc I; Couffinhal T; Arnal JF; Klingel K; Desgranges C; Dos Santos P; Charpentier F; Gadeau AP. 2010. Osteopontin expression in cardiomyocytes induces dilated cardiomyopathy. Circ Heart Fail 3(3):431-9. PubMed: 20200330MGI: J:194810
- Riess I; Sala V; Leo C; Demaria M; Gatti S; Gallo S; Fitou A; Boero O; Levi R; Cuccovillo I; Molla F; De Angelis N; Staszewsky L; Latini R; Crepaldi T. 2011. A mouse model for spatial and temporal expression of HGF in the heart. Transgenic Res 20(6):1203-16. PubMed: 21360304MGI: J:223066
- Sainte-Marie Y; Nguyen Dinh Cat A; Perrier R; Mangin L; Soukaseum C; Peuchmaur M; Tronche F; Farman N; Escoubet B; Benitah JP; Jaisser F. 2007. Conditional glucocorticoid receptor expression in the heart induces atrio-ventricular block. FASEB J 21(12):3133-41. PubMed: 17517920MGI: J:134842
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- Ziegler T; Horstkotte J; Schwab C; Pfetsch V; Weinmann K; Dietzel S; Rohwedder I; Hinkel R; Gross L; Lee S; Hu J; Soehnlein O; Franz WM; Sperandio M; Pohl U; Thomas M; Weber C; Augustin HG; Fassler R; Deutsch U; Kupatt C. 2013. Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis. J Clin Invest :. PubMed: 23863629MGI: J:201411