The GR strain carries five endogenous proviral copies of mouse mammary tumor virus (MMTV) including Mtv2. In GR, Mtv2 causes mammary carcinomas in 100% of breeding females prior to one year of age. Mtv2 deletes T cells carrying V beta 14 in the presence of MHC class II I-E (Ferrick 1992). This double congenic carries the GR Mtv2 locus in an exogenous and endogenous MMTV-free genetic background (WLC/MorJ, Stock No. 002600) and in an H2d background. This congenic represents a model for studying MMTV-induced mammary tumorigenesis in the absence of multiple endogenous proviruses (Morris 1986). Mammary tumor incidence has not been confirmed at The Jackson Laboratory.
WLC/MorJ (Stock #002600) was derived from inbreeding MMTV-free wild mice from Lake Casitas, CA. WLC/MorJ represents a endogenous and exogenous MMTV-free genetic background. WLC/MorJ is not permissive for MMTV expression. To permit expression, WLC/MorJ was made congenic for the BALB/c H2d locus. The Mtv2 locus has not been fully backcrossed to WLC/MorJ; it is believed to be 94% congenic (Morris, personal communication). The Jackson Laboratory received the colony in 1997.
|Allele Name||mammary tumor virus locus 2, present|
|Allele Type||Not Applicable|
|Gene Symbol and Name||Mtv2, mammary tumor virus locus 2|
|Strain of Origin||Not Applicable|
|General Note||The provirus is present in the following strains: GR/Imr, GR, and SHN/Mei.|
|Allele Name||d variant|
|Gene Symbol and Name||H2, histocompatibility-2, MHC|
|Strain of Origin||various|
|General Note||The d variant has been observed in the following strains: DBA/2, DBA/2J BALB/c, BALB/cByJ, BALB/cJ, C57BLKS, NZB.|