| Allele Name | transgene insertion 8, Raj P Kapur |
| Allele Type | Transgenic (Reporter) |
| Allele Synonym(s) | DBH-lacZ; DBH-nlacZ(2860-8) |
| Gene Symbol and Name | Tg(DBHn-lacZ)8Rpk, transgene insertion 8, Raj P Kapur |
| Gene Synonym(s) | |
| Promoter | DBH, dopamine beta-hydroxylase, human |
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| Expressed Gene | lacZ, beta-galactosidase, E. coli |
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| Site of Expression | CNS expression. Specifically, neurons of the locus ceruleus and other classic noradrenergic brain stem nuclei, sympathetic ganglion neurons, and adrenal chromaffin cells. Also in neurons of the enteric system, the retina, some sensory and all cranial parasympathetic ganglia, and some diencephalic and telencephalic brain nuclei. |
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| Strain of Origin | C57BL/6 x SJL |
| Chromosome | UN |
| General Note | This line was generated from founder 2860-8. LacZ expression is seen in neurons of the locus ceruleus and other classic noradrenergic brain stem nuclei, sympathetic ganglion neurons, and adrenal chromaffin cells. LacZ expression is also observed in neurons of the enteric system, the retina, some sensory and all cranial parasympathetic ganglia, and some diencephalic and telencephalic brain nuclei. |
| Molecular Note | A fragment of the human dopamine beta hydroxylase (DBH) gene, extending from a Sma1 site 5.8 kb upstream from the transcription start to an HpaII site 41 bp into the 5' untranslated region of exon 1, was fused to a bacterial beta-galactosidase reporter gene. |
