Mice deficient in p27kip are viable, but are larger than normal littermates, with increased cellularity of all tissues. The thymus and spleen are particularly enlarged. Homozygous mutant, Cdkn1b-null adult mice have a shortened lifespan due to the growth of benign intermediate lobe pituitary tumors. Female mice are infertile, with a follicular phase ovulatory block. Large doses of exogenous gonadotropin induce ovulation, but both implantation and intrauterine embryonic development is impaired. The mice demonstrate haploid-insufficient susceptibility to the development of adenomas in the pituitary, intestine and lung following exposure to gamma irradiation or chemical carcinogens.

These Cdkn1b knock-out mice exhibit an enlarged thymus and spleen and are susceptible to the development of adenomas upon induction by gamma irradiation or chemical carcinogens.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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