NOD.129S6(B6)-Cd4^tm1Knw/DvsJ

Stock number: 003090
Product name: NOD.Cd4^null
Research areas: Diabetes and Obesity Research, Immunology, Inflammation and Autoimmunity Research

Description

Mice homozygous for the Cd4^tm1Knw knock-out have a significant block in CD4⁺ T cell development and show a Class II restricted deficit in helper T cell activity and other T cell responses. These NOD Cd4-deficient mice have decreased susceptibility to autoimmune diabetes and thus are diabetes resistant.

Detailed description

The initiation of autoimmune insulin-dependent diabetes mellitus (IDDM) in the NOD mouse model entails MHC class I-restricted CD8 T cell responses against pancreatic beta cell antigens. CD8 T cells require helper functions provided by MHC class II-restricted CD4 T cells to exert their full diabetogenic effects. Mice homozygous for the Cd4^tm1Knw knock-out have a significant block in CD4⁺ T cell development and show a Class II restricted deficit in helper T cell activity and other T cell responses. These NOD Cd4-deficient mice, therefore, have decreased susceptibility to autoimmune diabetes and thus are diabetes resistant.

Allele

Symbol: Cd4^tm1Knw
Name: targeted mutation 1, Barbara B Knowles
MGI accession ID: MGI:1857143
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Cd4
Marker name: CD4 antigen
Chromosome: 6
Strain of origin: 129S/SvEv-Gpi1^c
Molecular note: A neomycin resistance gene was inserted into exon 5.