FVB.Cg-Tg(WapIgf1)39Dlr/J

Stock number: 003078
Product name: WAP-IGF-1

Description

These WAP-IGF-1 mice express a transgene containing the a rat insulin-like growth factor 1 (rIGF-1) driven by the mouse whey acidic protein (Wap promoter.

Detailed description

Mice homozygous for the WapIgf1 transgene are viable and fertile. The transgene is expressed at high levels during lactation and post-lactation. There were no obvious changes in mammary gland histomorphology during lactation, but at 5 to 10 days post-laction, there was a delay in involution and decreased apoptosis.

Allele

Symbol: Tg(WapIgf1)39Dlr
Name: transgene insertion 39, Derek LeRoith
MGI accession ID: MGI:3053848
Generation method: Transgenic
Attributes: Inserted expressed sequence
Marker symbol: Tg(WapIgf1)39Dlr
Marker name: transgene insertion 39, Derek LeRoith
Chromosome: UN
Strain of origin: (C57BL/6 x SJL)F2
Expressed genes: Igf1,insulin-like growth factor 1,rat
Molecular note: The transgene contains the mouse whey acidic protein promoter and a rat preproIgf1 cDNA (insulin-like growth factor 1), which lacks 186 bp sequence of exon 1 and exon 5. The cDNA encodes 38 bp of 5'UTR, 48 amino acids of the signal peptide, the 70 amino acid mature peptide, the 35 amino acid Ea trailer peptide, and 13 bp of 3'UTR.