These congenic mice carry a chromosomal segment from Chromosome 11 bounded by the colony stimulating factor 2 (Csf2) and an Mit marker and includes the insulin dependent diabetes susceptibility locus 4 (Idd4).
Dr. Edward Leiter, The Jackson Laboratory
|Allele Type||Gene Symbol||Gene Name|
|QTL||Idd4||insulin dependent diabetes susceptibility 4|
|Marker Symbol||Marker Name|
|Csf2||colony stimulating factor 2 (granulocyte-macrophage)|
|D11Mit42||DNA segment, Chr 11, Massachusetts Institute of Technology 42|
This strain is congenic for a 42 cM segment of Chr 11 extending from Csf2 (colony stimulating factor 2, granulocyte-macrophage) through D11Mit42 that includes the insulin dependent diabetes susceptibility locus Idd4.The name given this segment in the primary reference is c11. Upon histological examination of the pancreas, the incidence and severity of periinsulitis (perivascular, periductal and/or periislet infiltration by mononuclear cells) in B6.NOD-(Csf2-D11Mit42) mice were found to be similar to those in C57BL/6 controls.
Genomic segments found in earlier linkage studies to include diabetogenic loci were transferred in the laboratory of E.K. Wakeland from NOD/Uf to C57BL/6 by six successive backcrosses (to N7). Sibs of each lineage were then intercrossed to generate mice homozygous for each segment. Microsatellite analysis was used to type mice for loci in the regions of interest.
|Gene Symbol and Name||Idd4, insulin dependent diabetes susceptibility 4|
|Strain of Origin||NOD|
|General Note||This allele also confers decreased hepatic iNKT cell numbers on a C57BL/6 background.|
|Molecular Note||This allele confers susceptibility to insulin dependent diabetes compared to C57BL/10.|