These congenic mice carry a chromosomal segment from Chromosome 6 bounded by Mit markers and includes the insulin dependent diabetes susceptibility locus 6 (Idd6).
|Allele Type||Gene Symbol||Gene Name|
|QTL||Idd6||insulin dependent diabetes susceptibility 6|
|Marker Symbol||Marker Name|
|D6Mit54||DNA segment, Chr 6, Massachusetts Institute of Technology 54|
|D6Mit14||DNA segment, Chr 6, Massachusetts Institute of Technology 14|
This strain is congenic for a 24 cM segment of Chr 6 extending from D6Mit54through D6Mit14that includes the insulin dependent diabetes susceptibility locus Idd6.The name given this segment in the primary reference is c6. Upon histologic examination of the pancreas, the incidence and severity of periinsulitis (perivascular, periductal and/or periislet infiltration by mononuclear cells) of B6.NOD-(D6Mit54-D6Mit14) mice were found to be similar to those of C57BL/6 controls.
Genomic segments found in earlier linkage studies to include diabetogenic loci were transferred in the laboratory of E.K. Wakeland from NOD/Uf to C57BL/6 by six successive backcrosses (to N7). Sibs of each lineage were then intercrossed to generate mice homozygous for each segment. Microsatellite analysis was used to type mice for loci in the regions of interest.
|Gene Symbol and Name||Idd6, insulin dependent diabetes susceptibility 6|
|Strain of Origin||NOD|
|General Note||This allele also confers defective IFN-gamma response in NK cells on a C57BL/6 genetic background (J:85823).|
|Molecular Note||This allele confers impaired thymocyte proliferation compared to C57BL/6.|