B6;129S1-Il1r1^tm1Roml/J

Stock number: 003018
Product name: IL-1RI^-
Research areas: Cancer Research, Immunology, Inflammation and Autoimmunity Research

Description

Mice homozygous for Il1r1^tm1Roml exhibit a reduced inflammatory response and no response to interleukin-1 alpha or beta. IL1 receptor type I deficient mice have a reduced delayed type hypersensitivity response and are highly susceptible to infection by Listeria monocytogenes.

Detailed description

Mice homozygous for the Il1r1^tm1Roml targeted mutation exhibit a reduced inflammatory response and no response to interleukin-1 alpha or beta. IL1 receptor type I deficient mice have a reduced delayed type hypersensitivity response and are highly susceptible to infection by Listeria monocytogenes.

Allele

Symbol: Il1r1^tm1Roml
Name: targeted mutation 1, Mark A Labow
MGI accession ID: MGI:1857441
Generation method: Targeted
Attributes: Null/Knockout
Synonyms: IL-1RI^-; IL-1RI-deficient; IL-1rKO
Marker symbol: Il1r1
Marker name: interleukin 1 receptor, type I
Marker synonyms: CD121A; CRMO3; D2S1473; IL-1 receptor alpha chain; IL1R; IL-1R1; IL-1R-1; Il1r-1; IL1RA; IL-1R-alpha; IL-1RT1; IL-1RT-1; IL-iR; P80
Chromosome: 1
Strain of origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺
Molecular note: A neomycin resistance gene cassette replaced an ~1 kb region of the DNA that includes one exon of the gene, which encodes the signal peptide and contains a possible ATG initiation codon.