Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Radiation induced | Kitl | kit ligand |
The steel 18 Harwell mutation, then on a mixed C3H and 101 background, was imported in 1988 from Harwell into NCI, Frederick. There, Peter Donovan maintained it by backrossing to C3H/HeN and C3H/HeJ. In 1993 this mutation was imported from NCI to the laboratory of Eva Eicher at The Jackson Laboratory and the estimated backcross generation at that time was greater than N10. The Eicher laboratory then backcrossed this mutation onto a B6 background using both C57BL/6JEi and C57BL/6J.
Allele Name | steel 18 Harwell |
---|---|
Allele Type | Radiation induced |
Allele Synonym(s) | |
Gene Symbol and Name | Kitl, kit ligand |
Gene Synonym(s) | |
Strain of Origin | (C3H/HeH x 101/H)F1 |
Chromosome | 10 |
Molecular Note | This allele comprises a deletion that is cytologically apparent, removing ~2.5% of Chr 10. Southern blot analysis and pulsed field gel electrophoresis showed that this deletion is greater than 810kb. |
When using the steel 18 Harwell mouse strain in a publication, please cite the originating article(s) and include JAX stock #002993 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or Wild-type for Kitl<Sl-18H> |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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