B6;129S7-Inhba^tm1Zuk/J

Stock number: 002990
Product name: Inhba null
Research areas: Developmental Biology Research

Detailed description

Homozygous mice die within 24 hours of birth. They show craniofacial defects including a cleft palate.

Development

Exon 2 of the Inhba gene was replaced with a vector containing Hprt. The 129-derived AB2.1 ES cell line was used. It is on a mixed C57BL/6 x 129/SvEv genetic background.

Allele

Symbol: Inhba^tm1Zuk
Name: targeted mutation 1, Martin M Matzuk
MGI accession ID: MGI:1861957
Generation method: Targeted
Attributes: Null/Knockout
Synonyms: actbetaA^ml; Inhba-
Marker symbol: Inhba
Marker name: inhibin beta-A
Marker synonyms: activin beta-A; EDF; FRP
Chromosome: 13
Strain of origin: 129S7/SvEvBrd-Hprt1^b-m2
Molecular note: A PGK hprt cassette replaced exon 2 of the gene.