B6.129S7-Lrpap1^tm1Her/J

Stock number: 002987
Product name: RAP-
Research areas: Cardiovascular Research

Detailed description

Mice homozygous for the Lrpap1^tm1Her targeted mutation (commonly referred to as RAP) are viable and fertile. They have a functional deficiency of the low density lipoprotein receptor-related protein (LRP) with reduced amounts of LRP seen in both the liver and the brain of homozygotes.

Allele

Symbol: Lrpap1^tm1Her
Name: targeted mutation 1, Joachim Herz
MGI accession ID: MGI:1857214
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Lrpap1
Marker name: low density lipoprotein receptor-related protein associated protein 1
Chromosome: 5
Strain of origin: 129S7/SvEvBrd
Molecular note: A neomycin resistance cassette was inserted into sequences that encode the leader peptide. Immunoblot analysis of liver and brain did not detect the encoded protein in homozygous animals.
General note: ES cell line = JH1 or AB1 (129S7/SvEvBrd-Hprt⁺).