These Mdm2 knock-out mice exhibit developmental defects. They are suitable for use in applications related to the study of regulation of cell growth during development.
Dr. Stephen N. Jones, Univ of Massachusetts Medical School
Mice homozygous for a null mutation in Mdm2 die early in gestation, but are rescued in the absence of Trp53. Mdm2/Trp53-double null mice share the same phenotype as Trp53 mice.
|Allele Name||targeted mutation 1, Baylor College of Medicine|
|Allele Type||Targeted (Null/Knockout)|
|Allele Synonym(s)||Mdm2-; Mdm2delta7-12; mdm2ml|
|Gene Symbol and Name||Mdm2, transformed mouse 3T3 cell double minute 2|
|Strain of Origin||129S7/SvEvBrd-Hprtb-m2|
|Molecular Note||An hprt reporter replaced a 7.1 kb fragment of the gene encompassing all of exons 7 through 11 and a portion of exon 12. The deleted region encoded all of the putative transcription function motifs of the protein.|
|Mutations Made By|| |
Dr. Stephen Jones, Univ of Massachusetts Medical School
When maintaining a live colony, heterozygous mice may be bred to wildtype mice from the colony or to C57BL/6J inbred mice (Stock No. 000664). Homozygous die early in gestation.
When using the mdm2ml mouse strain in a publication, please cite the originating article(s) and include JAX stock #002968 in your Materials and Methods section.