These BALB/c congenic mice carry the Klra8Cmv1-r allele from C57BL/6 that confers resistance to lethal infection with murine cytomegalovirus (MCMV).
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Not Applicable | Klra8 | killer cell lectin-like receptor, subfamily A, member 8 |
This BALB/c congenic carries C57BL/6 alleles for loci in the natural killer cell gene complex (NKC) on mouse chromosome 6. The region contains Klra (formerly Ly49), Klrb1 (formerly Ly55) and Klra8. This strain is useful in tumor models involving NK cell regulation and the expression of NK1.1 on BALB/c background. It plays a role in elucidating the contribution of the NKC region in controlling infectious agents.
Made from donor strain C57BL/6 and recipient strain BALB/c. At each generation mice used in next backcross were screened for Cmvlr allele. After 10 generations of backcrossing, brother x sister matings were initiated to generate homozygous individuals. Representative mice from the colony maintained by Scalzo at University of Western Australia were sent to his collaborator Yokoyama at Washington University in St. Louis. The Yokoyama colony is the source of TJL mice.
Allele Name | cytomegalovirus resistance 1, resistant |
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Allele Type | Not Applicable |
Allele Synonym(s) | Cmv1r |
Gene Symbol and Name | Klra8, killer cell lectin-like receptor, subfamily A, member 8 |
Gene Synonym(s) | |
Strain of Origin | C57BL/6 |
Chromosome | 6 |
Molecular Note | Mapping experiments confirmed that the C57BL/6 strain contained the Klra8 gene, and expression of Klra8 correlated with the resistant phenotype. |
Litter sizes are reported to be similar to those of BALB/c inbred mice and can range up to 9-10 per litter.
When using the Cmv-1l mouse strain in a publication, please cite the originating article(s) and include JAX stock #002936 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous for Klra8<Cmv1-r>, 1 pair minimum |
Frozen Mouse Embryo | C.B6-Klra8Cmv1-r/UwaJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | C.B6-Klra8Cmv1-r/UwaJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | C.B6-Klra8Cmv1-r/UwaJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | C.B6-Klra8Cmv1-r/UwaJ Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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