CNCr.129P2-Cd40^tm1Kik/J

Stock number: 002927
Product name: CD40 KO
Strain synonyms: Tnfrsf5-
Research areas: Cancer Research, Immunology, Inflammation and Autoimmunity Research, Sensorineural Research

Description

Detailed description

Mice homozygous for the targeted mutation are viable and fertile. Homozygous mutant mice exhibit impaired immunoglobulin class switching and germinal center formation.

Allele

Symbol: Cd40^tm1Kik
Name: targeted mutation 1, Hitoshi Kikutani
MGI accession ID: MGI:1857457
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Cd40
Marker name: CD40 antigen
Chromosome: 2
Strain of origin: 129P2/OlaHsd
Molecular note: A neomycin cassette was inserted into exon 3. Disruption of the functionality of the protein was confirmed by a surface expression assay in spleen cells in which no binding of Tnfsf5 to ligand was observed.