These HuCIITg mice express a transgene containing the human APOC2 gene and the human CYP1A1 promoter.
Dr. Neil S. Shachter, Coll of Physicians & Surgeons,Columbia U
Genetic Background | Generation |
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Allele Type |
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Transgenic (Inserted expressed sequence, Humanized sequence) |
Mice carrying the human apolipoprotein CII transgene are viable and fertile. Transgenic mice show hypertriglyceridemia and have delayed clearance of VLDL-triglyceride. This strain is a model for hyper-triglyceridemia due to decreased lipolysis.
Expressed Gene | APOC2, apolipoprotein C2, human |
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Site of Expression |
Allele Name | transgene insertion 2, Jan L Breslow |
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Allele Type | Transgenic (Inserted expressed sequence, Humanized sequence) |
Allele Synonym(s) | apoC-II; CII |
Gene Symbol and Name | Tg(APOC2)2Bres, transgene insertion 2, Jan L Breslow |
Gene Synonym(s) | |
Promoter | CYP1A1, cytochrome P450 family 1 subfamily A member 1, human |
Expressed Gene | APOC2, apolipoprotein C2, human |
Strain of Origin | (C57BL/6J x CBA/J)F2 |
Chromosome | UN |
Molecular Note | The transgenic construct contains the human APOC2 gene and the human CYP1A1 promoter. |
Mutations Made By | Dr. Neil Shachter, Coll of Physicians & Surgeons,Columbia U |
This strain is maintained by mating hemizygous mice to wildtype sibllings. It is currently on a mixed CBA/J x C57BL/6J genetic background. Expected coat color from breeding:Black, White Bellied Agouti
When using the HuCIITg mouse strain in a publication, please cite the originating article(s) and include JAX stock #002925 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Hemizygous or Non carrier for Tg(APOC2)2Bres |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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