B6;CBA-Tg(APOC2)2Bres/J

Stock number: 002925
Product name: HuCIITg
Research areas: Cardiovascular Research

Description

These HuCIITg mice express a transgene containing the human APOC2 gene and the human CYP1A1 promoter.

Detailed description

Mice carrying the human apolipoprotein CII transgene are viable and fertile. Transgenic mice show hypertriglyceridemia and have delayed clearance of VLDL-triglyceride. This strain is a model for hyper-triglyceridemia due to decreased lipolysis.

Allele

Symbol: Tg(APOC2)2Bres
Name: transgene insertion 2, Jan L Breslow
MGI accession ID: MGI:3054893
Generation method: Transgenic
Attributes: Inserted expressed sequence; Humanized sequence
Marker symbol: Tg(APOC2)2Bres
Marker name: transgene insertion 2, Jan L Breslow
Chromosome: UN
Strain of origin: (C57BL/6J x CBA/J)F2
Expressed genes: APOC2,apolipoprotein C2,human
Molecular note: The transgenic construct contains the human APOC2 gene and the human CYP1A1 promoter.