Mice homozygous for the Tgfawa1 spontaneous mutation are recognizable at 2 or 3 days of age by their curly whiskers. The first coat is strongly waved and straight in later coats. Most of the whiskers also become straight, but the guard hairs are curved and shorter than normal. Some homozygotes have eyelids open at birth.
Ventricular enlargement and striatal reduction is observed in adult homozygous wa1 mice. The phenotype is more severe in males. In addition, adult males exhibit reduced hippocampal volume and impaired auditory and contextural fear learning. Both sexes demonstrate an abnormal fear response. Peripubertal mice do not exhibit behavioral deficits despite slight forebrain structural abnormalities. (Koshibu K, et al., 2005)
|Allele Name||waved 1|
|Allele Synonym(s)||wa-1; waved|
|Gene Symbol and Name||Tgfa, transforming growth factor alpha|
|Strain of Origin||Not Specified|
|Molecular Note||This allele was identified by a noncomplementation test with Tgfatm1Unc. Although the specific molecular lesion has not been identified, Northern blot analysis revealed that expression of TGFalpha transcript was reduced in homozygous mice.|