ABP.EL-El2^EL/FrkJ

Stock number: 002815
Product name: El-2

Detailed description

Mice from this congenic strain carry the El2^EL quantitative trait locus (QTL) from the EL/SuzSeyFrk strain and are characterized by a susceptibility to seizures.

Development

El2 was initially identified as a QTL contributing to idiopathic epilepsy in the EL/Suz inbred strain. It maps to chromosome 2. This locus was backcrossed onto the ABP/Le background until N6 then sibling mated to generate mice homozygous for the El2 locus. These mice have been subsequently maintained by sibling mating. The El2 congenic interval in this strain encompasses D2Mit43 and D2Mit21 sequences from EL/Suz, but has ABP/Le sequences at D2Mit11 and D2Mit55.

Allele

Symbol: El2^EL
Name: EL
MGI accession ID: MGI:2155257
Generation method: QTL
Marker symbol: El2
Marker name: epilepsy 2
Chromosome: 2
Strain of origin: EL
Molecular note: This allele confers susceptibility to epileptic seizures compared to ABP/LeJ.
General note: The EL mouse strain was developed from mice with an increased succeptibility for epilepsy. These mice were first reported as a spontaneous mutation arising in the DDY strain. The succeptibility for epilepsy was subsequently shown to be the result of alleles at two or more loci.