LEWES/EiJ was derived from wild mice trapped in Lewes, Delaware. LEWES has a pure M. m. domesticus genome. Wild-derived mice are genetically distinct from common laboratory mice for a number of complex phenotypic characteristics and are valuable tools for genetic mapping, evolution and systematics research. In 2014 this inbred strain began to produce mice with a white spot on the head located approximately between the ears at the midline. Efforts are being made to breed this phenotype out of the colony, but this may not prove possible.
Founder mice for the wild-derived strain LEWES were trapped in Lewes, Delaware. Mice were sent from M. Potter(NCI) to EM Eicher at The Jackson Laboratory in 1996 at inbreeding generation F34. The strain was maintained by sibling intercrossing and embryos were generated for cryopreservation in 2008 from F34+F25 parents. These were cryo-recovered in 2021 and again maintained by sibling intercrossing. These mice have a pure M. m. domesticus genome.
|Allele Type||Not Applicable (Not Specified)|
|Gene Symbol and Name||Cox7a2l, cytochrome c oxidase subunit 7A2 like|
|Strain of Origin||multiple strains|
|General Note||Querying the sequences of the Sanger Mouse Genomes Project reveals that the short allele with its 6 bp deletion exists in C57BL/6J, C57BL/10J, C57BL/6NJ, C58/J, BALB/cJ, C3H/HeH, 129S5/SvEvBrd, NZW/LacZ, and SEA/GnJ, but the long allele lacking the deletion exists in 129S1/SvImJ, A/J, AKR/J, BTBR T+ Itpr3tf/J, BUB/BnJ, C3H/HeJ, C57BR/cdJ, C57L/J, CAST/EiJ, CBA/J, DBA/1J, DBA/2J, FVB/NJ, I/LnJ, KK/HiJ, LEWES/EiJ, LP/J, MOLF/EiJ, NOD/ShiLtJ, NZB/BlNJ, NZO/HlLtJ, PWK/PhJ, RF/J, SPRET/EiJ, ST/bJ, WSB/EiJ, ZALENDE/EiJ.|
|Molecular Note||This allele encodes the long isoform with 113 amino acids. It is found in 129S2/SvPasCrl, CBA/CaOlaHsd, Hsd:ICR, and NZB/OlaHsd.|
use nesting material for this strain. These mice are hard to handle due to their wild-derived nature.
When using the LEWES/EiJ mouse strain in a publication, please include JAX stock #002798 in your Materials and Methods section.