B6;129S7-Srd5a1^tm1Mahe/J

Stock number: 002793
Product name: Srd5a1-
Research areas: Metabolism Research, Reproductive Biology Research

Description

Female Srd5a1 knock-out mice exhibit reduced litter sizes and an inability to initiate parturition.

Detailed description

Mice homozygous for this mutation are viable and fertile. Homozygous female mice show reduced litter sizes due to embryonic death of ~50% of embryos at embryonic day 11. About 2/3 of homozygous female mice also show an inability to initiate parturition. This strain may serve as a model for studying factors involved in parturition as well as maternal-fetal interactions necessary for maintenance of pregnancy.

Allele

Symbol: Srd5a1^tm1Mahe
Name: targeted mutation 1, Mala Mahendroo
MGI accession ID: MGI:1857454
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Srd5a1
Marker name: steroid 5 alpha-reductase 1
Chromosome: 13
Strain of origin: 129S7/SvEvBrd
Molecular note: A region encompassing promoter region and the a 3' portion of exon 1, encoding thr first 36 amino acids, was replaced by a neomycin selection cassette. Northern blot analysis of total RNA isolated from several organs showed an absence of transcript in homozygous mutant mice.