Female Srd5a1 knock-out mice exhibit reduced litter sizes and an inability to initiate parturition.
Dr. Mala Mahendroo, Univ of Texas Southwest Med Ctr Dallas
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Targeted (Null/Knockout) | Srd5a1 | steroid 5 alpha-reductase 1 |
Mice homozygous for this mutation are viable and fertile. Homozygous female mice show reduced litter sizes due to embryonic death of ~50% of embryos at embryonic day 11. About 2/3 of homozygous female mice also show an inability to initiate parturition. This strain may serve as a model for studying factors involved in parturition as well as maternal-fetal interactions necessary for maintenance of pregnancy.
Allele Name | targeted mutation 1, Mala Mahendroo |
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Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | 5alphaRKO; Srd5a1- |
Gene Symbol and Name | Srd5a1, steroid 5 alpha-reductase 1 |
Gene Synonym(s) | |
Strain of Origin | 129S7/SvEvBrd |
Chromosome | 13 |
Molecular Note | A region encompassing promoter region and the a 3' portion of exon 1, encoding thr first 36 amino acids, was replaced by a neomycin selection cassette. Northern blot analysis of total RNA isolated from several organs showed an absence of transcript in homozygous mutant mice. |
Mutations Made By | Dr. Mala Mahendroo, Univ of Texas Southwest Med Ctr Dallas |
When using the Srd5a1- mouse strain in a publication, please cite the originating article(s) and include JAX stock #002793 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or Wild-type for Srd5a1<tm1Mahe> |
Frozen Mouse Embryo | B6;129S7-Srd5a1<tm1Mahe>/J | $2595.00 |
Frozen Mouse Embryo | B6;129S7-Srd5a1<tm1Mahe>/J | $2595.00 |
Frozen Mouse Embryo | B6;129S7-Srd5a1<tm1Mahe>/J | $3373.50 |
Frozen Mouse Embryo | B6;129S7-Srd5a1<tm1Mahe>/J | $3373.50 |
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