DBA/1LacJ-Alox5ap^tm1Jdm/J

Stock number: 002787
Product name: FLAP-
Research areas: Immunology, Inflammation and Autoimmunity Research

Description

These Alox5ap knock-out mice exhibit resistance to zymosan stimulated inflammation. They may be useful in applications related to the studies of inflammation and arthritis.

Detailed description

Mice homozygous for the Alox5ap^tm1Jdm targeted mutation are viable and fertile. Homozygous mutant mice are resistant to zymosan stimulated inflammation. DBA/1LacJ mice carrying the null mutation for Alox5ap gene show a reduction in the severity of collagen-induced arthritis.

Allele

Symbol: Alox5ap^tm1Jdm
Name: targeted mutation 1, John D McNeish
MGI accession ID: MGI:1857167
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Alox5ap
Marker name: arachidonate 5-lipoxygenase activating protein
Chromosome: 5
Strain of origin: DBA/1LacJ
Molecular note: A PGK-neomycin selection cassette was inserted into coding sequences of the gene.
General note: Development of a DBA/1LacJ ES cell line enables gene targeting directly on the arthritis-susceptible background, as 129 ES cell lines generate mice that are not susceptible to collagen-induced arthritis (J:29897).