These Alox5ap knock-out mice exhibit resistance to zymosan stimulated inflammation. They may be useful in applications related to the studies of inflammation and arthritis.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Targeted (Null/Knockout) | Alox5ap | arachidonate 5-lipoxygenase activating protein |
Mice homozygous for the Alox5aptm1Jdm targeted mutation are viable and fertile. Homozygous mutant mice are resistant to zymosan stimulated inflammation. DBA/1LacJ mice carrying the null mutation for Alox5ap gene show a reduction in the severity of collagen-induced arthritis.
Allele Name | targeted mutation 1, John D McNeish |
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Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | FLAP; FLAP - |
Gene Symbol and Name | Alox5ap, arachidonate 5-lipoxygenase activating protein |
Gene Synonym(s) | |
Strain of Origin | DBA/1LacJ |
Chromosome | 5 |
General Note | Development of a DBA/1LacJ ES cell line enables gene targeting directly on the arthritis-susceptible background, as 129 ES cell lines generate mice that are not susceptible to collagen-induced arthritis (J:29897). |
Molecular Note | A PGK-neomycin selection cassette was inserted into coding sequences of the gene. |
Mutations Made By | John McNeish, Pfizer Central Research |
This strain is maintained by homozygous sibling matings.
When using the FLAP- mouse strain in a publication, please cite the originating article(s) and include JAX stock #002787 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Homozygous for Alox5ap<tm1Jdm>, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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