Mice homozygous for the Crhtm1Maj targeted mutation are viable and fertile. Pups born to homozygous mothers must be supplemented with corticosterone in the drinking water (10-30ug/ml) from day 12 of gestation until weaning. Homozygous mutant mice have reduced adrenocortical secretion following stress. They may be susceptible to complications from hypoglycemia when fasting. Heterozygous mice are phenotypically indistinguishable from wildtype siblings.

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These Crh knock-out mice exhibit reduced adrenocortical secretion following stress and may be susceptible to complications from hypoglycemia when fasting. They may be useful in applications related to the study of role of glucocorticoid during development.

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