Homozygous mice for the Cxcr2tm1Mwm knock-out have splenomegaly, lymphadenopathy, and impaired neutrophil migration. They may be useful for studies of inflammatory diseases.
Dr. Mark W. Moore, Deltagen
Mice homozygous for this targeted mutation are viable and fertile although the reproductive rate is lower than normal wildtype siblings. Homozygous mutant mice have splenomegaly, lymphadenopathy, and impaired neutrophil migration. Formerly referred to as Cmkar2, chemokine (C-X-C) receptor 2; also called Il8r, interleukin 8 receptor.
|Allele Name||targeted mutation 1, Mark Moore|
|Allele Type||Targeted (Null/Knockout)|
|Allele Synonym(s)||Cmkartm1Mwm; Cmkar2tm1Mwm; CXCR-; CXCR2-; CXCR2 -; Il8rbtm1Mwm; mCXCR-; mCXCR2-; mIL-8Rh-; mIL-8Rh KO|
|Gene Symbol and Name||Cxcr2, chemokine (C-X-C motif) receptor 2|
|Strain of Origin||129S2/SvPas|
|Molecular Note||A neomycin selection cassette replaced the entire coding sequence of the gene.|
|Mutations Made By|| |
Dr. Mark Moore, Deltagen
When maintaining a live colony, homozygous females are bred to heterozygous males (homozygous males are not recommended for breeding). Expected coat color from breeding is Albino.
When using the mIL-8Rh- mouse strain in a publication, please cite the originating article(s) and include JAX stock #002724 in your Materials and Methods section.