Mice homozygous for the hydrocephalus 3 spontaneous mutation (Hydinhy3) are usually identifiable at 3 to 5 days. Those with frank hydrocephalus die by 4 or 5 weeks of age. The lateral ventricles and the third ventricle are enlarged, the aqueduct of Sylvius and the fourth ventricle are only slightly affected, and there is some dilatation of the ventral subarachnoid cistern. The hydrocephalus seems to be due to a defect in the subarachnoid space under the calvarium caused by an abnormal postnatal differentiation of the arachnoid mater and pia mater which prevents their separation. Penetrance is incomplete.
Hydrocephalus 3 (Hydinhy3) arose spontaneously in a heterogeneous stock of laboratory mice (Gruneberg, H.1943.). The mutation was received at The Jackson Laboratory by Dr. M.C. Green from Dr. Gruneberg in 1961, then at approximately generation F10 after an outcross of the stock to CBA in 1954. The strain was brother by sister bred by test matings and was at F76 in 1983. In 1995 the inbred strain stopped breeding and an outcross was made to B6CBACaF1 Aw/A. Tested males were then continuously backcrossed to the hybrid. In 1996 untyped +/? Females were bred with proven heterozygous males to generate embryos for cryopreservation.
|Allele Name||hydrocephalus 3|
|Gene Symbol and Name||Hydin, HYDIN, axonemal central pair apparatus protein|
|Strain of Origin||Not Specified|
|Molecular Note||Matings between mice carrying a transgenic insertion allele in this gene and hy3 mice demonstrated that these two mutations fail to complement each other, and suggests that these two mutations are allelic and very likely result from disrupted function of the same gene or set of genes.|
When using the hydrocephalus 3 mouse strain in a publication, please cite the originating article(s) and include JAX stock #002703 in your Materials and Methods section.