B6.129P2-Nppa^tm1Unc/J

Stock number: 002685
Product name: proANP KO
Research areas: Cardiovascular Research

Detailed description

Homozygotes are viable and fertile. Homozygotes show elevated blood pressure on both high and low salt diets. Heterozygous mice show normal blood pressure on a low salt diet but elevated blood pressue on a high salt diet.

Allele

Symbol: Nppa^tm1Unc
Name: targeted mutation 1, University of North Carolina
MGI accession ID: MGI:1857231
Generation method: Targeted
Attributes: Null/Knockout
Synonyms: ANP-; proANP-
Marker symbol: Nppa
Marker name: natriuretic peptide type A
Marker synonyms: Anf; ANP; ATFB6; atrial natriuretic peptide; ATRST2; CDD; CDD-ANF; CDP; natriuretic peptide precursor A; PND; RATANF
Chromosome: 4
Strain of origin: 129P2/OlaHsd
Molecular note: 11 bp of exon 2 was replaced with a neomycin resistance gene via homologous recombination. Radioimmunoassay of plasma and atria from homozygous mutant animals did not detect protein product.