Mice homozygous for the Acetm1Unc targeted mutation lack both the somatic and testicular isozyme forms of the Ace gene. They show reduced viability prior to weaning. Surviving homozygotes are hypotensive with blood pressures ~35 mmHg lower than normal wildtype silbings. Heterozygous male mice have blood pressures 15-20 mmHg below wildtype siblings. Fertility of homozygous males is greatly impaired. Ten to twelve month old female homoygotes exhibit abnormal renal vessels and tubules, increased renin synthesis accompanied by an abnormal expression pattern.

These Ace knock-out mice exhibit show reduced viability prior to weaning and reduced blood pressure in adults. They are suitable for use in applications related to the study of hypertension.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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