B6.129P2-Ace^tm1Unc/J

Stock number: 002679
Product name: Act zero copy
Research areas: Cardiovascular Research, Internal/Organ Research

Description

These Ace knock-out mice exhibit show reduced viability prior to weaning and reduced blood pressure in adults. They are suitable for use in applications related to the study of hypertension.

Detailed description

Mice homozygous for the Ace^tm1Unc targeted mutation lack both the somatic and testicular isozyme forms of the Ace gene. They show reduced viability prior to weaning. Surviving homozygotes are hypotensive with blood pressures ~35 mmHg lower than normal wildtype silbings. Heterozygous male mice have blood pressures 15-20 mmHg below wildtype siblings. Fertility of homozygous males is greatly impaired. Ten to twelve month old female homoygotes exhibit abnormal renal vessels and tubules, increased renin synthesis accompanied by an abnormal expression pattern.

Allele

Symbol: Ace^tm1Unc
Name: targeted mutation 1, University of North Carolina
MGI accession ID: MGI:1857115
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Ace
Marker name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Chromosome: 11
Strain of origin: 129P2/OlaHsd
Molecular note: A neomycin selection cassette was inserted into exon 14 of the gene. Exon 14 encodes amino acids critical for the normal function of both isoforms of the protein.